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A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: A role for matrix metalloproteinase 9 and 2  Indranil Sinha, BA, Siddharth.

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Presentation on theme: "A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: A role for matrix metalloproteinase 9 and 2  Indranil Sinha, BA, Siddharth."— Presentation transcript:

1 A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: A role for matrix metalloproteinase 9 and 2  Indranil Sinha, BA, Siddharth Bethi, MBBS, Paul Cronin, MD, David M. Williams, MD, Karen Roelofs, DVM, Gorav Ailawadi, MD, Peter K. Henke, MD, Matthew J. Eagleton, MD, G. Michael Deeb, MD, Himanshu J. Patel, MD, Ramon Berguer, MD, PhD, James C. Stanley, MD, Gilbert R. Upchurch, MD  Journal of Vascular Surgery  Volume 43, Issue 2, Pages (February 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 A, Computed tomography (CT) scan of healthy aorta and intercostal arteries (arrows). The segment labeled P and confined by the arrows is defined as the posterior aortic wall. A, Anterior aortic wall; L, lumen. B, CT scan of a thoracic aortic aneurysm and intercostal arteries (arrows). Notice the increased length of the anterior wall (opposite the intercostals) compared with control aorta. There is less of an increase in length of the posterior wall. A, Anterior aortic wall; P, posterior aortic wall; L, lumen. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Thoracic aortic aneurysm specimen with a relatively preserved posterior wall between the intercostals and significant dilatation in the anterior portion of the aortic wall. Black arrows point to sites from which corresponding aortic tissue samples are taken. White arrows point to paired posterior intercostal arteries. The distal tissue samples are taken at the interface of aneurysmal and normal-appearing aorta. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 A, At the level of the aneurysm, matrix metalloproteinase-9 (MMP-9) expression is 4.3-fold higher in the anterior wall compared with the posterior wall. MMP-9 is minimally detectable in the distal aspects of the aneurysm. *P <.05. Data are reported as mean ± standard error. B, At the level of the aneurysm, MMP-2 expression is 3.2-fold higher in the posterior wall compared with the anterior wall. MMP-2 is present in the distal aspects of the aneurysm, although the level of expression is not significantly different from MMP-2 expression at the level of the aneurysm. *P < .05. Data are reported as mean ± standard error. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Immunohistochemical staining of matrix metalloproteinase 9 (MMP-9) in thoracic abdominal aneurysms (TAAs) demonstrates increased staining in the anterior wall (A) compared with the posterior wall (B) in a TAA. Arrows point to positive MMP-9 staining (×100 magnification). L lumen; M, media. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 Immunohistochemical staining of matrix metalloproteinase 2 (MMP-2) in thoracic abdominal aneurysms (TAAs) demonstrates decreased staining in the anterior wall (A) compared with the posterior wall (B) in a TAA. Arrows point to positive MMP-2 staining (×100 magnification). L, Lumen; M, media; A, adventitia. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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