1. TH2 Cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-γ and corticosteroids 
Fu-Qiang Wen, MD, PhD, Xiangde Liu, MD, Winfred Manda, MD, Yusuke Terasaki, Tetsu Kobayashi, MD, PhD, Shinji Abe, MD, PhD, Qiuhong Fang, MD, PhD, Ronald Ertl, BS, Lidia Manouilova, MD, PhD, Stephen I. Rennard, MD 
Journal of Allergy and Clinical Immunology 
Volume 111, Issue 6, Pages (June 2003)
DOI: /mai
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2. Fig. 1
Effect of TH2 cytokines on VEGF release by ASMC. ASMC were incubated with indicated concentrations of IL-4, IL-5, IL-10, or IL-13. Results are mean ± SEM of 3 separate experiments each performed in triplicate. ANOVA showed increased release of VEGF in IL-4-treated, IL-5-treated, and IL-13-treated cells (P < .01). *P < .05, Scheff'; test, compared with control. (Fig continued on following page.)
Journal of Allergy and Clinical Immunology  , DOI: ( /mai )
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3. Fig. 2
Effect of IFN-γ on VEGF release by ASMC. ASMC were incubated with serum-free DMEM alone (A) or containing 10 ng/mL IL-4 (B), IL-5 (C), or IL-13 (D) in the absence or presence of indicated concentrations of IFN-γ. Results are mean ± SEM of 3 separate experiments, each performed in triplicate. ANOVA showed decreased release of VEGF in IFN-γ-treated cells (P < .01). *P < .05, Scheffé test, compared with control. (Figure continued on following page.)
Journal of Allergy and Clinical Immunology  , DOI: ( /mai )
Copyright © 2003 Mosby, Inc. Terms and Conditions

4. Fig. 3
Effect of TGF-β on VEGF release and its modulation by IFN-γ. ASMC were incubated with serum-free DMEM containing 2.5 ng/mL TGF-β1, TGF-β2, or TGF-β3 in the absence or presence of 200 U/mL IFN-γ. Results are mean ± SEM of 3 separate experiments, each performed in triplicate. P < .005 after Bonferroni adjustment compared with control (*) or TGF-β-stimulated cells (#).
Journal of Allergy and Clinical Immunology  , DOI: ( /mai )
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5. Fig. 4
Effect of IL-1β and TNF-α on VEGF release and its modulation by IFN-γ. ASMC were incubated with serum-free DMEM in the absence or presence of indicated concentrations of IL-1β (A) or TNF-α (B) or were incubated with serum-free DMEM containing in 10 ng/mL IL-1β in the absence or presence of various concentrations of IFN-γ (C). Results are mean ± SEM of 3 separate experiments, each performed in triplicate. *P < .01, Student t test, compared with control. (Figure continued on following page.)
Journal of Allergy and Clinical Immunology  , DOI: ( /mai )
Copyright © 2003 Mosby, Inc. Terms and Conditions

6. Fig. 5
Effect of budesonide on release of VEGF by ASMC. ASMC were incubated with serum-free DMEM containing 10 ng/mL of IL-4, IL-5, IL-13, or IL-1β (A) or 2.5 ng/mL TGF-β1, TGF-β2, or TGF-β3 (B) in the absence or presence of 10−7 mol/L budesonide. Results are mean ± SEM of 3 separate experiments, each performed in triplicate. P < .005 after Bonferroni adjustment compared with control (*) or cytokine-stimulated cells (#).
Journal of Allergy and Clinical Immunology  , DOI: ( /mai )
Copyright © 2003 Mosby, Inc. Terms and Conditions