1. Development and Function of Dendritic Cell Subsets
Alexander Mildner, Steffen Jung 
Immunity 
Volume 40, Issue 5, Pages (May 2014)
DOI: /j.immuni
Copyright © 2014 Elsevier Inc. Terms and Conditions

2. Figure 1
Development of cDC Subsets and Profiles of Key Transcription Factor Profiles
DCs arise from common monocyte-DC precursors (MDPs) in the BM, which differentiate into common monocyte progenitors (cMoPs) or common DC precursors (CDPs). CDPs can give rise to pDCs or pre-DCs that display considerable heterogeneity. Zbtb46-expressing pre-DCs are committed cDC precursors, which reach lymphoid and nonlymphoid tissues via the circulation. The heat map depicts the expression of selected key DC transcription factors throughout the commitment. Arrows within the heat map fields indicate phenotype of transcription-factor-deficient mice in different populations. The down arrow (↓) indicates a reduction in mutant mice, up arrow (↑) an increase, and horizontal arrow (↔) unchanged numbers of the cells. Asterisk indicates reduced expression of E2-2 may favor the conversion of pDCs into CD8+CX3CR1+ splenic DCs.
Immunity  , DOI: ( /j.immuni )
Copyright © 2014 Elsevier Inc. Terms and Conditions

3. Figure 2 Surface Phenotype of DCs
cDCs in lymphoid and nonlymphoid tissue differentiate from a circulating pre-DC. Within the tissue, the different cDC subsets can be divided according to the indicated cell surface markers.
Immunity  , DOI: ( /j.immuni )
Copyright © 2014 Elsevier Inc. Terms and Conditions