1. Gene-environment interaction in chronic disease: A European Science Foundation Forward Look 
Harald Renz, MD, Ingo B. Autenrieth, MD, Per Brandtzæg, PhD, William O. Cookson, MD, DPhil, Stephen Holgate, DSc, Erika von Mutius, MD, Rudolf Valenta, MD, Dirk Haller, PhD 
Journal of Allergy and Clinical Immunology 
Volume 128, Issue 6, Pages S27-S49 (December 2011)
DOI: /j.jaci
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Development of chronic inflammatory disease is a dynamic event. After initiation, the disease process involves acute inflammation that moves toward chronicity and tissue remodeling, as well as regeneration. These events are controlled by both intrinsic and extrinsic determinants. The grand challenges in this area are the development of prevention (primary, secondary, and tertiary), as well as the development of causal therapies.
Journal of Allergy and Clinical Immunology  , S27-S49DOI: ( /j.jaci )
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Metabolic and immune-mediated pathologies with inflammatory processes in various target organs as the key driver of disease initiation, perpetuation, or both. Extrinsic and intrinsic events (red text) lead to the manifestation of disease (black text).
Journal of Allergy and Clinical Immunology  , S27-S49DOI: ( /j.jaci )
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig 3
Strategic recommendations for future research into chronic inflammatory disease.
Journal of Allergy and Clinical Immunology  , S27-S49DOI: ( /j.jaci )
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5. Fig 4
Influencing fields affecting future research into chronic inflammatory disease.
Journal of Allergy and Clinical Immunology  , S27-S49DOI: ( /j.jaci )
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6. Fig 5 Factors influencing research into chronic inflammatory disease.
Journal of Allergy and Clinical Immunology  , S27-S49DOI: ( /j.jaci )
Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions