1. Selectivity-determining regions
Nonconserved amino acids in the proximity of the PTP active site (yellow)
are involved in recognition of peptide substrates and non-peptide PTP inhibitors
WPD-loop specificity
F182
SHP specificity region
S118
D48
R47
R24
G259
KNRY-loop
specificity
Second pTyr binding site
The degree of conservation (blue – most conserved, red least conserved) reflects the Ca-regiovariation score
values of 37 aligned human PTP catalytic domains.
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Andersen et al Mol. Cell. Biol. 2001