Download presentation
Presentation is loading. Please wait.
Published byHartono Halim Modified over 5 years ago
1
Impact of Human Leukocyte Antigen Allele Mismatch in Unrelated Bone Marrow Transplantation with Reduced-Intensity Conditioning Regimen Hisayuki Yokoyama, Junya Kanda, Shigeo Fuji, Sung-Won Kim, Takahiro Fukuda, Yuho Najima, Hitoshi Ohno, Naoyuki Uchida, Yasunori Ueda, Tetsuya Eto, Koji Iwato, Hikaru Kobayashi, Yukiyasu Ozawa, Tadakazu Kondo, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda Biology of Blood and Marrow Transplantation Volume 23, Issue 2, Pages (February 2017) DOI: /j.bbmt Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions
2
Figure 1 Unadjusted overall survival (OS) and disease-free survival (DFS) for each number of mismatched alleles in HLA-A, -B, -C, and -DRB1 loci in unrelated bone marrow transplantation with reduced-intensity conditioning. (A) The curves represent OS for 8/8 match, 1-allele mismatch (7/8 match), and 2-allele mismatch (6/8 match). (B) The curve represents DFS for 8/8 match, 1-allele mismatch (7/8 match), and 2-allele mismatch (6/8 match). Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions
3
Figure 2 Cumulative incidence rates of acute GVHD (aGVHD) and chronic GVHD (cGVHD), relapse, and non-relapse mortality (NRM) for each number of HLA-mismatched alleles in HLA-A, -B, -C, and -DRB1 loci in unrelated bone marrow transplantation with reduced-intensity conditioning. (A) aGVHD grade 2-4, (B) aGVHD grade 3-4, (C) cGVHD, (D) relapse, and (E) NRM. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions
4
Figure 3 Unadjusted overall survival (OS) and disease-free survival (DFS) for 1-allele mismatch at each locus at HLA-A, -B, -C, and -DRB1 in unrelated bone marrow transplantation with reduced-intensity conditioning. (A) The curves represent OS for 8/8 match, and 1-allele mismatch at HLA-A or -B (A or B mismatch), HLA-C (C mismatch), and HLA-DRB1 (DRB1 mismatch). (B) The curves represent DFS for 8/8 match, and 1-allele mismatch at HLA-A or -B (A or B mismatch), HLA-C (C mismatch), and HLA-DRB1 (DRB1 mismatch). Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions
5
Figure 4 Cumulative incidence rates of acute GVHD (aGVHD) and chronic GVHD (cGVHD), relapse, and nonrelapse mortality (NRM) for 1-allele mismatch at each locus at HLA-A, -B, -C, and -DRB1 in unrelated bone marrow transplantation with reduced-intensity conditioning. (A) aGVHD grades 2 to 4, (B) aGVHD grades 3 and 4, (C) cGVHD, (D) relapse, and (E) NRM. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.