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Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle.

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Presentation on theme: "Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle."— Presentation transcript:

1 Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris  James J. Leyden, MD, Lincoln Krochmal, MD, Alex Yaroshinsky, PhD  Journal of the American Academy of Dermatology  Volume 54, Issue 1, Pages (January 2006) DOI: /j.jaad Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Schematic profile of randomized controlled study.
Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Mean percent reduction (SE) in inflammatory lesion counts from baseline to week 12 (end of treatment; intent-to-treat population). Asterisk, P ≤ versus combination gel (parametric analysis of variance model with last observation carried forward). Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Mean percent reduction (SE) in noninflammatory lesion counts from baseline to week 12 (end of treatment; intent-to-treat population). Asterisk, P ≤ versus combination gel (parametric analysis of variance model with last observation carried forward). Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Mean percent reduction (SE) in total lesion counts from baseline to week 12 (end of treatment; intent-to-treat population). Asterisk, P ≤ versus combination gel (parametric analysis of variance model with last observation carried forward). Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

6 Fig 5 Kaplan-Meier curve of the time to 50% reduction in subject's total lesion counts. Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

7 Fig 6 Investigator's Static Global Assessment (ISGA): Percentage of subjects with clear or almost clear skin (success) at week 12 (end of treatment; intent-to-treat population). Asterisk, P ≤ versus combination gel (Cochran-Mantel-Haenszel test [α = .05] stratified by site with last observation carried forward). Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

8 Fig 7 Images of typical patient at baseline (A) and after treatment with combination hydrogel at week 12 (B). Journal of the American Academy of Dermatology  , 73-81DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

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