1. Donor Treatment With the Lazeroid U74389G Reduces Ischemia–Reperfusion Injury in a Rat Lung Transplant Model 
Bernard Hausen, Peter Mueller, Marcus Bahra, Raj Ramsamooj, Randall E Morris, Charles W Hewitt 
The Annals of Thoracic Surgery 
Volume 64, Issue 3, Pages (September 1997)
DOI: /S (97)

2. Fig. 1
Model design. Double-lung block is implanted through custom-designed stents to the vessels of the left hilum of the recipient. Donor graft is ventilated through a separate ventilator. Serial assessment includes donor-specific oxygenation, graft vascular resistance, dynamic lung compliance, and airway resistance. (A/D = analog-to-digital; LAP = left atrial pressure; P.art. = pulmonary artery; PAP = pulmonary artery pressure; PC = personal computer; P.ven. = pulmonary vein.)
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

3. Fig. 2
Serial measurements of dynamic lung compliance. Donor pretreatment significantly improved graft compliance during reperfusion. (Repeated-measures analysis of variance: groups I/II p < ; groups I/III p < ; groups I/IV p < ; groups II/IV p < 0.045; groups III/IV p < )
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

4. Fig. 3
Airway resistance, measured in cm H20 · L−1 · s−1, is significantly lower if the donor animal was pretreated with the lazeroid U74389G when compared with untreated controls and recipient treatment. (Repeated-measures analysis of variance: groups I/II p < ; groups I/III p < ; groups II/IV p < ; groups II/III p < 0.03; groups III/IV p < 0.05.)
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

5. Fig. 4
Comparison of alveolar–arterial oxygen difference. In untreated controls and the recipient treatment group the alveolar–arterial oxygen difference was significantly higher than in donor pretreated animals. (Repeated-measures analysis of variance: groups I/II p < ; groups I/III p < ; groups I/IV p < ; groups II/IV p < ; groups III/IV p < )
The Annals of Thoracic Surgery  , DOI: ( /S (97) )

6. Fig. 5
Resistance to pulmonary blood flow measured in mm Hg · mL−1 · min−1 is markedly elevated in the recipient treatment group with minimal blood flow at the onset of reperfusion. (Repeated-measures analysis of variance: groups I/II p < ; groups I/III p < ; groups I/IV p < ; groups II/III p < 0.03; groups III/IV p < 0.04.)
The Annals of Thoracic Surgery  , DOI: ( /S (97) )