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Fig. 3 BMS-986165 blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS-986165 blocks functional responses in primary immune.

Published byJukka-Pekka Melasniemi Modified over 5 years ago

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Presentation on theme: "Fig. 3 BMS-986165 blocks functional responses in primary immune cells driven by IL-23 and IL-12. BMS-986165 blocks functional responses in primary immune."— Presentation transcript:

1 Fig. 3 BMS-986165 blocks functional responses in primary immune cells driven by IL-23 and IL-12.
BMS blocks functional responses in primary immune cells driven by IL-23 and IL-12. (A) Effect of BMS on IL-23–induced STAT3 phosphorylation in the CD161+CD3+ TH17 population in human PBMCs (representative flow cytometry dot plot and phospho-STAT3 histogram shown). The data are representative of three independent experiments with two independent replicates within the experiment. (B) Effect of BMS on IL-17A production from CD4+ mouse TH17 cells induced upon coculture with IL-23, PGE2, anti-CD3, and anti-CD28. The data represent means ± SEM shown for three independent replicates within this experiment. (C) Effect of BMS on IL-12–induced production of IFNγ in human PBMCs. The data are representative of eight independent experiments with means ± SEM shown for three independent replicates within this experiment. James R. Burke et al., Sci Transl Med 2019;11:eaaw1736 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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