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Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice  Kazuki Hirahara,

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Presentation on theme: "Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice  Kazuki Hirahara,"— Presentation transcript:

1 Oral administration of a dominant T-cell determinant peptide inhibits allergen-specific TH1 and TH2 cell responses in Cry j 2–primed mice  Kazuki Hirahara, MSa, Saburo Saito, MDb, Nobufusa Serizawa, PhDa, Reiko Sasaki, MDc, Masahiro Sakaguchi, PhDc, Sakae Inouye, MDc, Yoshifumi Taniguchi, MEd, Shuichi Kaminogawa, PhDe, Akio Shiraishi, PhDa  Journal of Allergy and Clinical Immunology  Volume 102, Issue 6, Pages (December 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Proliferative responses of nasally-associated lymph node cells against Cry j 1, Cry j 2, and T-cell determinant peptides of Cry j 2. Results are indicated as mean ± SD of cpm. I.n., Intranasal. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

3 Fig. 2 Proliferative responses of LNCs from mice fed with p (A) or p70-83 (B) before being primed intranasally (I.n.) with Cry j 1 and Cry j 2. Results are indicated as mean ± SD of cpm. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

4 Fig. 3 Inhibited anti-Cry j 2 IgE (A) and IgG (B) antibody responses in mice fed with p before being primed intranasally (I.n.) with Cry j 2. Data are presented as mean ± SD. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

5 Fig. 4 Inhibited serum anti-Cry j 2 IgE antibody response in mice fed with p before being primed intraperitoneally (I.p.) with Cry j 2 and alum. Data are presented as mean ± SD. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

6 Fig. 5 Inhibited proliferative response of LNCs from mice fed with p after being primed intranasally (I.n.) with Cry j 2. Results are indicated as mean ± SD of cpm. *P < .01 versus control group of mice. Journal of Allergy and Clinical Immunology  , DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions

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