1. Interoperability with SNOW SHRINE
James R. Campbell MD
Scott Campbell PhD
Jay Pedersen MS
Yeshwanth Narayana
James McClay MD
Nebraska Medicine
University of Nebraska Medical Center

2. I2b2 research network interoperation in SHRINE
Hypothesis: We are entering an era of interoperable research network dominance
Requires OBSERVATION_FACTs to be CONCEPT_CDed with relevant, historically complete standard terminologies/ontologies (or mapped from local terms)
Shared deployment of standard ontology set as i2b2 metadata across all network spokes which references all coded content
Adapter mappings for networked query support

3. ONC Terminology Model for Semantic Interoperability
Demographics: LOINC
Problem list: SNOMED CT
Encounter and billing diagnoses: (ICD-9-CM), ICD-10-CM
Lab results (observables): Lab LOINC
Physical findings: LOINC
Medication orders: RxNORM
Medication dispense & administration records: NDC
Procedures: ICD-10-PCS, CPT, HCPCS

4. Fall 2017 SCILHS (ARCH) metadata analysis
40% or better of medication fact data was not accessible with SCILHS ontology; historical meds were missing entirely
Laboratory metadata referenced no more than 10% of UNMC facts, rendering the data useless
ICD-10-CM out of date
RxNorm, NDC and LOINC ontology builds from UNMC evaluated by JK and agreed as useful for ARCH; I have no update on ARCH deployment

5. SNOW SHRINE

6. SNOW SHRINE Metadata 2018 Metadata concepts 20180330 20181001
ICD-10-CM
92073
93522
LOINC (lab/pathology)
1662
1880
RxNorm
107693
109154
NDC
517620
527401
SNOMED CT Conditions
N/A
124503
Procedures(CPT, ICD*)
250833
LOINC (clinical)
334

7. ACT network cooperation
Met with Michelle Morris (UPitt) who is technical lead and data harmonization team repeatedly
UNMC shared Snow SHRINE lab ontology set which they used to seed their own effort
Shared medication metadata and found their approach to be similar but extracted from UMLS and therefore incomplete
No commitment for collaboration on ontology layer which would conceivably save many GPC sites dual employment of SHRINE