1. Group B
Presenters: Erinne Munie, Tyler Roneker, Peter Marcote, Erik Freedmen
Supported by our lovely researchers and assistants

2. The Basis of the CAMELWAK
No loose tubes
Secure fixtures
No exposed surfaces
Quick replacement procedures
Quick water release
Water regenerating system
Minimal costs
No hospitalizations
Normal life activity
Individualization of dialysis treatment X

3. You can go anywhere and do anything with the CamelWak

4. Toxin and Solute Removal
Function of dialysis
Remove uremic toxins and retain endotoxins through diffusion, convection, and ultrafiltration
The
Reliable hemodialysis filter
Electrochemical filtration water regenerating system
Maintaining X Flow rate with continuous renal replacement therapy

5. Solute Removal Diagram
Key features
Additional slack in blood tubing
Easily chargeable at nights
Easy water release mechanism
Simple nightly replacement procedures
Inexpensive because mostly reusable

6. Hemodialysis Filter Utilization of countercurrent flow
Traditional filter: Multiflow M60 hemofilter with SA of 0.6m^2 and K=1.5
Utilizes pulsatile push pull internal hemodiafiltration mechanism of the WAK
Dialysate and blood with a half cycle phase differential
Enhances transfer of middle molecular weight molecules through dialyzer membrane

7. Traditional vs. Sorbent vs. Electrochemical
Solute Removal systems
Traditional
The good
4 hours dialysis
High Kt/V
The bad
immobilization
Hospitalizations
200 L of water
High urea fluctuations
High water losses
Sorbent System
The good
Filters dialysate into ultra pure water
Uses 375 milliliters of water
The bad
Non reusable sorbent filters
High cost due to constant replacement of sorbent filters
Electrochemical system
The good
Filters dialysate into ultra pure water
Uses 375 milliliters of water
Reusable
Inexpensive because not replaced regularly
No hospitalizations

8. Electrochemical Filtration Water Regenerating System
Input: dialysate from hemodialysis filter with the addition of urease
Objective: Remove all remaining solutes to create purified H2O
Ions pass through semi-permeable membrane from an electric potential gradient
Negative and positive ions or proteins are attracted to the electrically charged surface
The only non-charged molecule is urea
Which is broken down by urease into a charged particle

9. Electrochemical Filtration System
Negative
Na+ K+
CO2-
Ca+
Mg+
Cr+
Positive
Cl-
HCO3- P-
Albumin
Molecules leaving Dialysate
Need Citation

10. Dialysate in the CamelWak
Electrolyte sensor after dry acid addition
Future: Individualization of bulk concentrated solutions
Patient’s clinical hemostatic electrolyte concentration
Concentrate added through a dry acid addition line with constant release
Electrochemical sensor included as a check
Bicarbonate buffer at 30-35mol/L will be released at a controlled rate

11. Dialysis Comparisons Old Method 1 Liter of acid concentrate
1.575 Liters of liquid bicarbonate concentration
Liters of purified water
Total: 45 Liters of Dialysis
Amplified to about 200L for hospital dialysis
New Method
Dry Acid Concentrates
Dissolves in pure water
Our pulsatile flow would help dissolve the concentrate
Dry on Line Bicarbonate Concentrates
Microbiologically safe
Chemically stable
Small and lightweight
All dialysates tend to have the same concentations to a certain degree.
With dry acid concentrates we can personalize treatments

12. Diagram In the back is the water removal reservoir
In the front is a hard piece of plastic where dialysis components can snap into to ensure security and control space
On the bottom you can see the release valve

13. Nightly Procedure Charge batteries while sleeping (1 minute)
Disconnect aseptic connections and throw away hemodialysis filter unit and tubing (2 minutes)
Connect the new hemodialysis filter unit (5 minutes)
Disconnect, Urea enzyme, concentrate, buffer and hormones (2 minutes)
Drain electrochemical filtration regenerating system (5 minutes)
Reload entire system with water (5minutes)
In the morning, add new concentrates (2 minutes)
Your ready to GO! Total time: (22 minutes)
Insert picture of draining and filling unit

14. Questions for water group
Are we doing an app to check blood pressure before and returning
What about electrolyte sensor
What about a water sensor on the water reservoir
Are all these Bluetooth to the cell phone