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Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor–Induced Upper Airway Angioedema Richard Sinert, DO, Phillip Levy, MD, MPH, Jonathan A. Bernstein, MD, Richard Body, MB ChB, PhD, Marco L.A. Sivilotti, MD, MSc, Joseph Moellman, MD, Jennifer Schranz, MD, Jovanna Baptista, MS, Alan Kimura, MD, PhD, Wolfram Nothaft, MD The Journal of Allergy and Clinical Immunology: In Practice Volume 5, Issue 5, Pages e3 (September 2017) DOI: /j.jaip Copyright © 2017 The Authors Terms and Conditions
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Figure 1 Flow diagram of subjects. The intention-to-treat population comprised all randomized subjects (N = 121). The modified intention-to-treat population comprised all randomized subjects who received the study drug (n = 118). The safety population comprised all subjects who received the study drug (n = 118). *Discharged from hospital approximately 13 hours after treatment having met discharge criteria, but could not be reached for the day 3 safety follow-up. The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip ) Copyright © 2017 The Authors Terms and Conditions
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Figure 2 Kaplan-Meier plots. A, Time to meeting discharge criteria by treatment group. B, TOSR by treatment group (intention-to-treat population). Subjects who did not achieve the end point within the observation period were censored at the last observation time. One subject (icatibant group) who achieved the end points at 96 hours posttreatment was not plotted in this graph. The Journal of Allergy and Clinical Immunology: In Practice 2017 5, e3DOI: ( /j.jaip ) Copyright © 2017 The Authors Terms and Conditions
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