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IL-18 might reflect disease activity in mild and moderate asthma exacerbation  Hiroshi Tanaka, MD, Naomitsu Miyazaki, MD, Kensuke Oashi, MD, Shin Teramoto,

Published byBjørn-Erik Halvorsen Modified over 5 years ago

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Presentation on theme: "IL-18 might reflect disease activity in mild and moderate asthma exacerbation  Hiroshi Tanaka, MD, Naomitsu Miyazaki, MD, Kensuke Oashi, MD, Shin Teramoto,"— Presentation transcript:

1 IL-18 might reflect disease activity in mild and moderate asthma exacerbation 
Hiroshi Tanaka, MD, Naomitsu Miyazaki, MD, Kensuke Oashi, MD, Shin Teramoto, MD, Masanori Shiratori, MD, Midori Hashimoto, MD, Mitsuhide Ohmichi, MD, Shosaku Abe, MD  Journal of Allergy and Clinical Immunology  Volume 107, Issue 2, Pages (February 2001) DOI: /mai Copyright © 2001 Mosby, Inc. Terms and Conditions

2 Fig. 1 Serum IL-18 levels in patients with stable and acute asthma, patients with pulmonary sarcoidosis, and healthy control subjects. Dotted line represents the lower limit of the IL-18 assay. Significantly higher values of serum IL-18 were found in patients with acute asthma (P = .02) and patients with pulmonary sarcoidosis (P = .008) than in healthy control subjects. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

3 Fig. 2 Circulating IFN-γ levels in patients with stable and acute asthma, patients with pulmonary sarcoidosis, and healthy control subjects. Dotted line represents the lower limit of the IFN-γ assay. Significantly higher values of serum IFN-γ were found in patients with pulmonary sarcoidosis (P < .0001) than in healthy control subjects. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

4 Fig. 3 Relationship between circulating IL-18 and IFN-γ levels in patients with pulmonary sarcoidosis. There is a significant positive correlation (r = 0.61, n = 35, P < .001). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

5 Fig. 4 Paired serum IL-18 levels in 13 of 23 patients with acute asthma on exacerbation and remission days. IL-18 levels during acute asthma are significantly higher than those on remission days (P = .01). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

6 Fig. 5 Serial changes in IL-18 levels in 16 of 23 patients with acute asthma treated with steroid infusion. A significantly higher PEF value is found on day 7 after asthma therapy than on day 1. There are significant decreases of serum IL-18 levels on both days 3 and 7. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

7 Fig. 6 Relationship between circulating IL-18 levels and sIL-2R or ECP levels in acute asthma. There is a significantly positive correlation between circulating IL-18 and sIL-2R levels (r = 0.77, n = 23, P < .0001); however, there is no correlation between serum IL-18 and ECP values. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

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