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Presence of anti-HPV E6/E7 epitope CD8+ T-cell responses in HPV+ OPSCC tumors.
Presence of anti-HPV E6/E7 epitope CD8+ T-cell responses in HPV+ OPSCC tumors. Tumors from HPV+ patients with OPSCC were assessed for the presence of CD8+ T-cell responses to the HLA-A*0201-restricted HPV E6/E7 epitopes, LLMGTLGIV (LV9), TIHDIILECV (TV10), and KLPQLCTEL (KL9) using dextramers. A, A representative dot plot showing the presence of all 3 reactivities in a tumor. B, Quantification of responses to all three epitopes (LV9, TV10, and KL9) from 5 HPV+ OPSCC tumors. Emma Reeves et al. Cancer Immunol Res 2019;7: ©2019 by American Association for Cancer Research
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