1. Drug response profiles and experimental validation.
Drug response profiles and experimental validation. (A and B) Drug response profiles for gemcitabine and doxorubicin predicted by the computational model (A) and experimental validation using small-molecule inhibitors of ATR, CHK1, DNA-PK, and ATM (B). For the analysis, the drug and inhibitor concentrations were varied over a wide range, and outcome is quantified after 3 days. The black line indicates the stasis line as predicted by the computational model. Blue stars represent the low-dose chemotherapy, and the red stars indicate the high-dose chemotherapy in combination with a targeted inhibitor as chosen for the single-dose combinations (Fig. 4). The dashed white boxes indicate areas where the model prediction and experimental data are discordant.
Ozan Alkan et al., Sci. Signal. 2018;11:eaat0229
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