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Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM-1 (CD54) and its natural ligand LFA-1 (CD11a/CD18)  Marcello Bagnasco, MDa, Giampaola.

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Presentation on theme: "Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM-1 (CD54) and its natural ligand LFA-1 (CD11a/CD18)  Marcello Bagnasco, MDa, Giampaola."— Presentation transcript:

1 Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM-1 (CD54) and its natural ligand LFA-1 (CD11a/CD18)  Marcello Bagnasco, MDa, Giampaola P. Pesce, BSa, Antonio Caretto, MDb, Francesca Paolieri, MDa, Caterina Pronzato, MDa, Barbara Villaggio, BSc, Carla Giordano, MDd, Corrado Betterle, MDb, G.W. Canonica, MDa  Journal of Allergy and Clinical Immunology  Volume 95, Issue 5, Pages (May 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 FIG. 1 Follicular APAAP staining (red) by the CD54 mAb 84H10 in a patient with HT (original magnification, ×500). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 FIG. 2 Follicular APAAP staining by the CD11a mAb in a Hashimoto's specimen. Identical results were obtained with the other CD11a mAb (8F2.7) (original magnification, ×500). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 FIG. 3 Follicular CD11a (25.3.1) staining in HT (indirect immunofluorescence-phycoerythrin) (original magnification, ×500). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 FIG. 4 Double immunofluorescence with anti-TPO-positive human serum and CD11a (8F2.7) mAb in a section of HT tissue. Diffuse follicular green fluorescence caused by TPO is apparent; some follicular portions are double-stained (orange fluorescence), that is, LFA-1-positive (arrows). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 FIG. 5 Double staining of a follicular portion with CD11a (25.3.1) and CD54 staining (as indicated by amaranth color) in HT (original magnification, ×1000). Journal of Allergy and Clinical Immunology  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions


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