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Good Response to Gefitinib in Lung Adenocarcinoma Harboring Coexisting EML4-ALK Fusion Gene and EGFR Mutation  Yao-Wen Kuo, MD, Shang-Gin Wu, MD, Chao-Chi.

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Presentation on theme: "Good Response to Gefitinib in Lung Adenocarcinoma Harboring Coexisting EML4-ALK Fusion Gene and EGFR Mutation  Yao-Wen Kuo, MD, Shang-Gin Wu, MD, Chao-Chi."— Presentation transcript:

1 Good Response to Gefitinib in Lung Adenocarcinoma Harboring Coexisting EML4-ALK Fusion Gene and EGFR Mutation  Yao-Wen Kuo, MD, Shang-Gin Wu, MD, Chao-Chi Ho, MD, PhD, Jin-Yuan Shih, MD, PhD  Journal of Thoracic Oncology  Volume 5, Issue 12, Pages (December 2010) DOI: /JTO.0b013e3181f43274 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Compared with the initial computed tomography (CT) of thorax (A) and the repeated CT 92 days after gefitinib treatment (B), dramatic shrinkage of right upper lobe mass was shown. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f43274) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A mutant form of epidermal growth factor receptor (EGFR) del 2235–2249 (del E746-A750) in exon 19 (upper panel) and a variant 1 of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) translocation (lower panel) were identified by reverse transcription-polymerase chain reaction and sequencing assays. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181f43274) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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