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Update on risk factors for food allergy

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1 Update on risk factors for food allergy
Gideon Lack, MD  Journal of Allergy and Clinical Immunology  Volume 129, Issue 5, Pages (May 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Dual-allergen exposure hypothesis for the pathogenesis of FA. Allergic sensitization results from cutaneous exposure, and tolerance occurs as a result of oral exposure to food. GI, Gastrointestinal. Reprinted with permission from Lack.1 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 PA among children with FA (n = 293) as a function of environmental exposure depending on whether child first ate peanuts by 12 months of age. Reprinted with permission from Fox et al.67 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Early consumption of peanuts in infancy is associated with a low prevalence of PA. Adapted from Du Toit et al.13 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Ratio of stimulation index (SI) in the cutaneous lymphocyte antigen (CLA) subset relative to the SI in the α4β7 subset for patients with PA (n = 10) and nonallergic patients (NA; n = 10) with 400 μg/mL peanut antigen and OVA. Median values are represented by bars. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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