Presentation is loading. Please wait.

Presentation is loading. Please wait.

Establishing a Target Exposure for Once-Daily Intravenous Busulfan Given with Fludarabine and Thymoglobulin before Allogeneic Transplantation  James A.

Similar presentations


Presentation on theme: "Establishing a Target Exposure for Once-Daily Intravenous Busulfan Given with Fludarabine and Thymoglobulin before Allogeneic Transplantation  James A."— Presentation transcript:

1 Establishing a Target Exposure for Once-Daily Intravenous Busulfan Given with Fludarabine and Thymoglobulin before Allogeneic Transplantation  James A. Russell, Shahbal B. Kangarloo, Tyler Williamson, M. Ahsan Chaudhry, Mary Lynn Savoie, A. Robert Turner, Loree Larratt, Jan Storek, Nizar J. Bahlis, Mona Shafey, Christopher B. Brown, Maggie Yang, Michelle Geddes, Nancy Zacarias, Ping Yue, Peter Duggan, Douglas A. Stewart, Andrew Daly  Biology of Blood and Marrow Transplantation  Volume 19, Issue 9, Pages (September 2013) DOI: /j.bbmt Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Kaplan-Meier plots of grade II-IV aGVHD (A) and grade III-IV aGVHD (B). Groups 1 and 2 (solid line) had a Bu AUC below the median, whereas groups 3 and 4 (dotted line) had a Bu AUC above the median. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Kaplan-Meier plots of OS (A), DFS (B), and NRM (C). Groups 1 and 4 (dotted line) had a Bu AUC outside the range of 3814 to 4993 μM/min, whereas groups 2 and 3 (solid line) had a Bu AUC within that range. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Kaplan-Meier plots of relapse.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions


Download ppt "Establishing a Target Exposure for Once-Daily Intravenous Busulfan Given with Fludarabine and Thymoglobulin before Allogeneic Transplantation  James A."

Similar presentations


Ads by Google