1. Natural killer cell biology: An update and future directions
Kerry S. Campbell, PhD, Jun Hasegawa, PhD 
Journal of Allergy and Clinical Immunology 
Volume 132, Issue 3, Pages (September 2013)
DOI: /j.jaci
Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Models of NK cell education. During NK cell development, only some of the stochastically expressed inhibitory receptors (KIR in human subjects and Ly49 in mice) recognize self MHC-I ligand (SRIR). SRIR interactions promote NK cell education to mediate cytotoxicity toward an abnormal cell that has lost MHC-I expression, whereas a mature NK cell expressing only unliganded inhibitory receptors becomes hyporesponsive. Models of NK cell education are indicated as follows: (1) Rheostat, expression of more than 1 SRIR promotes more robust education; (2) Cis Interaction, interactions between SRIRs and MHC-I on the NK cell surface restrict SRIR from the immune synapse; (3) Arming, inhibitory signaling blocks chronic activation signals that would otherwise anergize (Disarming); and (4) Licensing, an ITIM-mediated signal drives education.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions