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Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease  Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro.

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Presentation on theme: "Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease  Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro."— Presentation transcript:

1 Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease 
Fabio L.M. Ricciardolo, MD, Gaetano Caramori, MD, PhD, Kazuhiro Ito, PhD, Armando Capelli, MD, Paola Brun, PhD, Giovanni Abatangelo, MD, Alberto Papi, MD, Kian Fan Chung, MD, Ian Adcock, PhD, Peter J. Barnes, MD, Claudio F. Donner, MD, Andrea Rossi, MD, Antonino Di Stefano, PhD  Journal of Allergy and Clinical Immunology  Volume 116, Issue 5, Pages (November 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of NT+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of iNOS+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of eNOS+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Photomicrographs showing the bronchial mucosa from a nonsmoker (A), a smoker with normal lung function (B), a patient with mild/moderate COPD (C), and a subject with severe COPD (D) immunostained for identification of MPO+ cells (arrows) in the submucosa. Results are representative of those from 11 nonsmokers, 13 smokers with normal lung function, 14 patients with mild/moderate COPD, and 13 patients with severe COPD. E, Epithelium. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

6 Fig 5 Regression analysis between postbronchodilator FEV1 % predicted (A and C), FEV1/FVC % (B and D), and numbers of NT+ (A and B) and MPO+ (C and D) cells in the submucosa of all patients with COPD. Correlation coefficients were calculated by using the Spearman rank method. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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