1. Hemodynamic stability during 17 years of the carpentier-edwards aortic pericardial bioprosthesis 
Michael K Banbury, MD, Delos M Cosgrove, MD, James D Thomas, MD, Eugene H Blackstone, MD, Jeevanantham Rajeswaran, MS, J.Edward Okies, MD, Robert M Frater, MD 
The Annals of Thoracic Surgery 
Volume 73, Issue 5, Pages (May 2002)
DOI: /S (02)

2. Fig 1
Evolution of New York Heart Association (NYHA) functional class across time in the Premarket Approval cohort (n = 267). Symbols represent the proportion of patients in each class in 1-year intervals. Closed circles = NYHA class I, open circles = class II, squares = class III, and triangles = class IV. In this depiction, death is a censoring mechanism. Solid lines = the solution for an ordinal logistic longitudinal repeated-measures model with only time as a variable.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

3. Fig 2
Evolution of mean transvalvular gradient across time. Actual data points are shown, coded for each labeled valve size as follows: closed circle = 19-mm prostheses; open circle = 21-mm prostheses; square = 23-mm prostheses; triangle = 25-mm prostheses; and X = 29-mm prostheses. Solid lines = estimates of mean gradient for each valve size across time (Table 4).
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

4. Fig 3
Evolution of in vivo effective orifice area (EOA) across time. Format is as in Figure 2, plus diamond = 27-mm prostheses.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

5. Fig 4
Evolution of left ventricular ejection fraction in women (A) and in men (B). Format is as in Figure 2, plus diamond = 27-mm prostheses.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )

6. Fig 5
Development of aortic valve regurgitation across time. Symbols represent the percentage of patients in each regurgitation grade in 3-year intervals. Closed circles = regurgitation grades 0 (none) and trace; open circles = grade 1+ (mild); squares = grade 2+ (moderate); and triangles = grade 3+ and 4+ (severe). Solid lines = the solution for an ordinal logistic longitudinal repeated-measures model with only time as a variable (equation not shown). The ordinal model can be thought of as a set of compartments in which there is transition from grade 0 or trace to grade 1+, then to 1+ to 2+, and finally to grade 3+ and 4+. Thus, the proportion of patients in grade 0 or trace decreased across time, the proportion in grade 1+ rose and then plateaued (it eventually will decrease), and the other two grades increased.
The Annals of Thoracic Surgery  , DOI: ( /S (02) )