1. Fibroblast responses to changes in miR-21-5p and miR-29 family levels
Fibroblast responses to changes in miR-21-5p and miR-29 family levels. miR-21-5p and miR-29 family members can act synergistically to potentiate fibroblast functions in fibrotic conditions.
Fibroblast responses to changes in miR-21-5p and miR-29 family levels. miR-21-5p and miR-29 family members can act synergistically to potentiate fibroblast functions in fibrotic conditions. The figure shows complex but established relationships supported by the literature review. Above the horizontal line is the activation of a profibrotic fibroblast in both idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). Below the line represents the normal state. Highlighted on the right surrounding the abstract fibroblast is the mechanism by which both miRNAs can regulate transforming growth factor (TGF)-β release from its latency-associated peptide (LAP) by stimulating integrin expression and collagen synthesis. The right-hand fibroblast image also shows the effect of miRNAs 21-5p and the 29 family on α-SMA expression. Small mother against decapentaplegic protein (SMAD)3 has a pivotal role in the maintenance of the loop of this finely regulated system: SMAD3 stimulates the secretion of miR-21-5p, which blocks the inhibitory effect of SMAD7 on SMAD3; in addition, SMAD3 reduces miR-29 family levels, which reinforces SMAD3 activation.
Gianluca Bagnato et al. Eur Respir Rev 2017;26:160125
©2017 by European Respiratory Society