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Chronic digitalis administration alters mesenteric vascular reactivity

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Presentation on theme: "Chronic digitalis administration alters mesenteric vascular reactivity"— Presentation transcript:

1 Chronic digitalis administration alters mesenteric vascular reactivity
Edwin H. Kim, B.A., Bruce L. Gewertz, M.D.  Journal of Vascular Surgery  Volume 5, Issue 2, Pages (February 1987) DOI: / (87) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Experiments were performed in denervated isoperfused rat intestinal preparations. Temperature was maintained at 37° C. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Change in mesenteric blood flow vs. perfusion pressure. Blood flow was autoregulated in both groups of rats until perfusion pressure was decreased below 50 mm Hg. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Oxygen consumption was maintained at normal levels until perfusion pressure decreased below 40 mm Hg. Oxygen extraction (A-VO2 difference) increased as flow was reduced. There were no differences between digitalis-treated and control rats. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Effect of acute venous hypertension in rats that received long-term digitalis therapy. Digitalis-treated animals demonstrated significant increases in mesenteric vascular resistance and more severe reduction in oxygen consumption than control rats. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 In patients who receive digitalis treatment, sudden increases in portal pressure accompanying cardiac decompensation could trigger an enhanced myogenic response in the mesenteric circulation. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

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