1. VAL-MARC: Change in systolic blood pressure (SBP) at 6 weeks by treatment assignment
End point
Valsartan
Valsartan+HCTZ p
Change in SBP at 6 weeks (primary BP end point) (mm Hg)
-18
-25
<0.001
Proportion of patients reaching goal (%) 32 48
<0.0001
Ridker PM et al. Hypertension 2006; Available at:

2. VAL-MARC: Median change in hs-CRP at 6 weeks by treatment assignment
Measure
Valsartan
Valsartan + HCTZ p
hs-CRP median (mg/dL)
Baseline
2.11
2.07
6 weeks
1.98
2.15
Median change (mg/dL)
-0.12
+0.05
<0.001
Median change (%)
-8.9
+4.4
Ridker PM et al. Hypertension 2006; Available at: