1. TH2 adjuvants: Implications for food allergy
M. Cecilia Berin, PhD, Wayne G. Shreffler, MD, PhD 
Journal of Allergy and Clinical Immunology 
Volume 121, Issue 6, Pages (June 2008)
DOI: /j.jaci
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Possible mechanisms of allergic sensitization to gatrointestinal antigen. Antigen (Ag) complex is sampled by the gut-associated immune system via M cells or across enterocytes. Antigen delivery to APCs, such as DCs, is enhanced by physical factors such as antigen stability or compromised epithelial barrier. Instrinsic or associated features of allergens (listed next to lightning bolts) may then activate DCs and other innate immune cells to enhance signals that instruct naive T cells to differentiate preferentially to a TH2 phenotype. These innate signals may include membrane-bound ligands expressed on DCs, such as OX40L, TIM-4, and Jagged, that interact with their respective receptors on T cells, as well as soluble mediators from other cells, such as IL-4 and TSLP. Treg, Regulatory T cell.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )
Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions