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Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin- induced asthma  Yukio Kawagishi, MDa,b, Haruhisa Mita, PhDb, Masami Taniguchi,

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Presentation on theme: "Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin- induced asthma  Yukio Kawagishi, MDa,b, Haruhisa Mita, PhDb, Masami Taniguchi,"— Presentation transcript:

1 Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin- induced asthma 
Yukio Kawagishi, MDa,b, Haruhisa Mita, PhDb, Masami Taniguchi, MDb, Muneharu Maruyama, MDa, Rokuo Oosaki, MDa, Noritaka Higashi, MDb, Tatsuhiko Kashii, MDa, Masashi Kobayashi, MDa, Kazuo Akiyama, MDb  Journal of Allergy and Clinical Immunology  Volume 109, Issue 6, Pages (June 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Basal levels of urinary LTE4 in each group. Horizontal bars indicate geometric means. Patients with wild-type and variant-type alleles are expressed as open and filled circles , respectively. *P < .001 compared with the control group; **P < compared with the control group; †P < compared with the ATA group. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 Ratio of increase in urinary LTE4 after aspirin challenge. The data are presented as means ± SEM of the percent increase over the prechallenge basal levels. Patients with wild-type and variant-type alleles are expressed as open and filled bars , respectively. *P < .05 compared with wild-type patients at 6 hours after aspirin challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions


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