Presentation is loading. Please wait.

Presentation is loading. Please wait.

Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries  Kimihiro Komori, MD, Hiroaki Shimokawa,

PublishFrank Hofer Modified over 5 years ago

Similar presentations

Presentation on theme: "Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries  Kimihiro Komori, MD, Hiroaki Shimokawa,"— Presentation transcript:

1 Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries  Kimihiro Komori, MD, Hiroaki Shimokawa, MD, Paul M. Vanhoutte, MD, PhD  Journal of Vascular Surgery  Volume 10, Issue 3, Pages (September 1989) DOI: / (89) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

2 Fig. 1 Tension recordings in isolated iliac arteries from a control (left) and a cholesterol-fed pig (right). Platelets were added to the organ chamber during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L) and ketanserin (10−6 mol/L). W0, Washout. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

3 Fig. 2 Left, Effects of methiothepin and apyrase on platelet-induced relaxations in iliac artery rings with endothelium from control pigs. Right, Endothelium-dependent relaxations to aggregating platelets in iliac arteries from control and cholesterol-fed pigs. The relaxations were examined during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L) and ketanserin (10−6 mol/L). The asterisk denotes a significant difference (p < 0.05) between the control and cholesterol-fed pigs. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

4 Fig. 3 Cumulative concentration-response curves to ADP in iliac arteries from control and cholesterol-fed pigs during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L) in the presence of indomethacin (10−5 mol/L). The effects of apyrase on ADP-induced relaxation in control vessels with the endothelium are also shown. The asterisk denotes a significant difference (p < 0.05) between the control and cholesterol-fed pigs. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

5 Fig. 4 Cumulative concentration-response curves to serotonin in iliac arteries from control and cholesterol-fed pigs during a contraction evoked by prostaglandin F2α (2 × 10−6 mol/L), in the presence of ketanserin (10−6 mol/L) and indomethacin (10−5 mol/L). The effects of methiothepin on serotonin-induced relaxations in control arteries with the endothelium are also shown. The asterisk denotes a significant difference (p < 0.05) between the two groups. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

6 Fig. 5 Effects of aggregating platelets (75,000/μl) in quiescent rings of iliac arteries from control and cholesterol-fed pigs, in the presence of indomethacin (10−5 mol/L). Effects of dazoxiben (10−5 mol/L), ketanserin (10−5 mol/L), and methiothepin (10−6 mol/L) on the platelet-induced contractions in rings without endothelium are also shown. The asterisk denotes a statistically significant difference between rings with and without endothelium, and the dagger shows a significant difference (p < 0.05) between arteries from control and cholesterol-fed pigs. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

7 Fig. 6 Cumulative concentration-response curves to serotonin in quiescent rings of iliac arteries from control and cholesterol-fed pigs in the presence of indomethacin (10−5 mol/L). Effects of ketanserin (10−6 mol/L) on serotonin-induced contractions of rings without endothelium are also shown. The ED30 for serotonin-induced contractions in rings without endothelium averaged 6.6 ± 0.2 − log mol/L and 6.5 ± 0.2 − log mol/L (n = 6) in rings of control and cholesterol-fed pigs, respectively (not significantly different). The asterisk denotes a statistically significant difference (p < 0.05) between rings with and without endothelium, and the dagger shows a significant difference (p < 0.05) between arteries from control and cholesterol-fed pigs. Journal of Vascular Surgery  , DOI: ( / (89) ) Copyright © 1989 Society for Vascular Surgery and International Society for Cardiovascular Surgery North American Chapter Terms and Conditions

Download ppt "Hypercholesterolemia impairs endothelium-dependent relaxations to aggregating platelets in porcine iliac arteries  Kimihiro Komori, MD, Hiroaki Shimokawa,"

Similar presentations

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,
The role of arteriovenous shunts in the pathogenesis of varicose veins Howard C. Baron, M.D., Sebastiano Cassaro, M.D. Journal of Vascular Surgery Volume.

The role of arteriovenous shunts in the pathogenesis of varicose veins Howard C. Baron, M.D., Sebastiano Cassaro, M.D. Journal of Vascular Surgery Volume.
Platelet survival and serotonin content after placement of arterial prostheses in dogs: Effects of neointimal coverage and high- and low-dose aspirin G.Patrick.

Platelet survival and serotonin content after placement of arterial prostheses in dogs: Effects of neointimal coverage and high- and low-dose aspirin G.Patrick.
The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.

The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.
A review of 100 consecutive reconstructions of the distal vertebral artery for embolic and hemodynamic disease  Ramon Berguer, MD, PhD, Mark D. Morasch,

A review of 100 consecutive reconstructions of the distal vertebral artery for embolic and hemodynamic disease  Ramon Berguer, MD, PhD, Mark D. Morasch,
Urokinase treatment preserves endothelial and smooth muscle function in experimental acute arterial thrombosis  David Whitley, MD, Peter Gloviczki, MD,

Urokinase treatment preserves endothelial and smooth muscle function in experimental acute arterial thrombosis  David Whitley, MD, Peter Gloviczki, MD,
Popliteal artery stenosis caused by a Baker's cyst

Popliteal artery stenosis caused by a Baker's cyst
Heparin-coated catheters and heparin-induced thrombocytopenia

Heparin-coated catheters and heparin-induced thrombocytopenia
Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism  Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,
Elastin, collagen, and some mechanical aspects of arterial aneurysms

Elastin, collagen, and some mechanical aspects of arterial aneurysms
Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease  Joseph P. Archie, PhD, MD  Journal of Vascular.
Ultrasound measurement of the luminal diameter of the abdominal aorta and iliac arteries in patients without vascular disease  Ole Martin Pedersen, MD,

Ultrasound measurement of the luminal diameter of the abdominal aorta and iliac arteries in patients without vascular disease  Ole Martin Pedersen, MD,
Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine–induced injury in human internal thoracic.

Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine–induced injury in human internal thoracic.
Wei Zhou, MD, Hong Chai, MD, PhD, Peter H. Lin, MD, Alan B

Wei Zhou, MD, Hong Chai, MD, PhD, Peter H. Lin, MD, Alan B
Volume 116, Issue 2, Pages (February 1999)

Volume 116, Issue 2, Pages (February 1999)
Mycotic axillary artery aneurysm

Mycotic axillary artery aneurysm
Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD 

Marilyn J. Cipolla, MS, Christian T. Harker, PhD, John M. Porter, MD 
A new valvulotome for in situ bypass grafts

A new valvulotome for in situ bypass grafts
Endothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts  Kimihiro Komori, MD, Peter Gloviczki,

Endothelium-dependent vasorelaxations in response to aggregating platelets are impaired in reversed vein grafts  Kimihiro Komori, MD, Peter Gloviczki,
Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1  Paul J. Pearson,

Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1  Paul J. Pearson,

Similar presentations

Ads by Google