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Biomarker Analyses from a Randomized, Placebo-Controlled, Phase IIIb Trial Comparing Bevacizumab with or without Erlotinib as Maintenance Therapy for.

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Presentation on theme: "Biomarker Analyses from a Randomized, Placebo-Controlled, Phase IIIb Trial Comparing Bevacizumab with or without Erlotinib as Maintenance Therapy for."— Presentation transcript:

1 Biomarker Analyses from a Randomized, Placebo-Controlled, Phase IIIb Trial Comparing Bevacizumab with or without Erlotinib as Maintenance Therapy for the Treatment of Advanced Non-Small-Cell Lung Cancer (ATLAS)  Fairooz Kabbinavar, MD, FACP, Louis Fehrenbacher, MD, John Hainsworth, MD, Saifuddin Kasubhai, MD, Bruce Kressel, MD, Thomas Marsland, MD, Taral Patel, MD, Mark Rubin, MD, Leonard White, MD, James Chih-Hsin Yang, MD, PhD, Barbara Klughammer, PhD, Dawn Colburn, PharmD, Vincent Miller, MD, Bruce E. Johnson, MD  Journal of Thoracic Oncology  Volume 9, Issue 9, Pages (September 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 CONSORT diagram for biomarker-evaluable patients. Note: a full study CONSORT diagram is available in Johnson et al.7 Note: Patients with missing or unevaluable biomarker status were excluded from the biomarker evaluable patients. EGFR, epidermal growth factor receptor; FISH, fluorescence in-situ hybridization; IHC, immunohistochemistry; ITT, intent-to-treat. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 PFS in patients included in the ATLAS (A) biomarker-evaluable and (B) ITT populations. OS in the ATLAS (C) biomarker-evaluable and (D) ITT populations (data cutoff: July 18, 2008). B + E, bevacizumab plus erlotinib; B + P, bevacizumab plus placebo; HR, hazards ratio; ITT, intent-to-treat; OS, overall survival; PFS, progression-free survival. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Progression-free survival (PFS) in patients with (A) EGFR mutation-positive tumors (B) KRAS wild-type tumors. B + E, bevacizumab plus erlotinib; B + P, bevacizumab plus placebo; HR, hazards ratio; Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Progression-free survival (PFS) and overall survival (OS) in biomarker subgroups. B + E, bevacizumab plus erlotinib; B + P, bevacizumab plus placebo; HR, hazards ratio. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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