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A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis

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Presentation on theme: "A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis"— Presentation transcript:

1 A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis
Elaine Pashupati Dopfer, Susana Minguet, Wolfgang W.A. Schamel  Immunity  Volume 35, Issue 2, Pages (August 2011) DOI: /j.immuni Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 TCR Internalization and Trogocytosis in T Cells
Constitutive TCR turnover occurs in resting cells. Upon stimulation, TCR nanoclusters aggregate to signaling-active microclusters that can be internalized in the pSMAC in a clathrin-dependent manner. Once the microclusters have reached the cSMAC, patches of the APC containing the pMHC molecules are trogocytosed with a TC21- and RhoG-dependent mechanism. Trogocytosed membrane proteins from the APC can be re-expressed on the T cell. Immunity  , DOI: ( /j.immuni ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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