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Impacts of pulsatile systemic circulation on endothelium-derived nitric oxide release in anesthetized dogs  Toshihide Nakano, MD, Ryuji Tominaga, MD,

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Presentation on theme: "Impacts of pulsatile systemic circulation on endothelium-derived nitric oxide release in anesthetized dogs  Toshihide Nakano, MD, Ryuji Tominaga, MD,"— Presentation transcript:

1 Impacts of pulsatile systemic circulation on endothelium-derived nitric oxide release in anesthetized dogs  Toshihide Nakano, MD, Ryuji Tominaga, MD, Shigeki Morita, MD, Munetaka Masuda, MD, Ichiro Nagano, MD, Ken-ichi Imasaka, MD, Hisataka Yasui, MD  The Annals of Thoracic Surgery  Volume 72, Issue 1, Pages (July 2001) DOI: /S (01)

2 Fig 1 The bar graphs show pulse rate-related changes in (A) dp/dt max (the maximum rate of pressure velocity) and (B) df/dt max (the maximum rate of flow velocity) before and after L-NAME at a fixed pulse pressure of 50 mm Hg. No differences were observed in the two variables at 30, 60, and 120 bpm, and they were not changed by L-NAME. Values are the mean ± standard error of the mean. (L-NAME = NG-Nitro-L-arginine Meythl Ester; PR= pulse rate.) The Annals of Thoracic Surgery  , DOI: ( /S (01) )

3 Fig 2 The bar graph shows changes in plasma NO2−/NO3− concentration (A). The line graph shows percent changes in total systemic vascular resistance before (○) and after (•) L-NAME (B). Note that plasma NO2−/NO3− concentration showed small but significant increase in response to the rise in pulse rate (p = 0.003) and that the changes in total systemic vascular resistance associated with pulse rate disappeared after L-NAME. Values are the mean ± standard error of the mean. (PR = pulse rate.) ∗p < compared by two-way repeated measures of analysis of variance. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

4 Fig 3 The bar graphs show pulse pressure-related changes in (A) dp/dt max (the maximum rate of pressure velocity) and (B) df/dt max (the maximum rate of flow velocity) before and after L-NAME at a fixed pulse rate of 120 bpm. Both dp/dt max and df/dt max significantly increased in response to the rise in pulse pressure. These variables were not changed by L-NAME. Values are the mean ± standard error of the mean. (PR = pulse rate.) The Annals of Thoracic Surgery  , DOI: ( /S (01) )

5 Fig 4 The bar graph shows changes in plasma NO2−/NO3− concentration (A). The line graph shows percent changes in total systemic vascular resistance before (○) and after (•) L-NAME (B). Note that plasma NO2−/NO3− concentration showed a small but significant increase in response to the rise in pulse pressure (p < 0.001) and that the changes in total systemic vascular resistance associated with pulse pressure disappeared after L-NAME. Values are the mean ± standard error of the mean. (PP = pulse pressure.) ∗p < compared by two-way repeated measures of analysis of variance. The Annals of Thoracic Surgery  , DOI: ( /S (01) )

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