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Adenoviral-mediated uteroglobin gene transfer inhibits neointimal hyperplasia after balloon injury in the rat carotid artery  Robert A. Larson, MD, Mina.

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Presentation on theme: "Adenoviral-mediated uteroglobin gene transfer inhibits neointimal hyperplasia after balloon injury in the rat carotid artery  Robert A. Larson, MD, Mina."— Presentation transcript:

1 Adenoviral-mediated uteroglobin gene transfer inhibits neointimal hyperplasia after balloon injury in the rat carotid artery  Robert A. Larson, MD, Mina Naji, MS, Joseph V. Lombardi, MD, Ali Naji, MD, PhD, Brigitte Koeberlein, AS, Michael A. Golden, MD  Journal of Vascular Surgery  Volume 32, Issue 6, Pages (December 2000) DOI: /mva Copyright © 2000 Society for Vascular Surgery and The American Association for Vascular Surgery, a Chapter of the International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Uteroglobin protein detection by Western blot. Western blot detection of rat uteroglobin in protein extracts from arteries treated with (1) Ad.UG (1.35 × 1011 pfu/mL), (2) Ad.LacZ, (3) PBS vehicle, along with untreated rat aorta (Ao ) and rat lung. Equal amounts of protein (8 μg) were loaded onto each lane. The primary antibody was a rabbit antirat uteroglobin polyclonal. PBS, Phosphate-buffered saline. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and The American Association for Vascular Surgery, a Chapter of the International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Morphometry results. Morphometry data from animals humanely killed 2 weeks after injury, expressed as I/M area ratio. Group treated with Ad.UG at 1.35 × 1011 pfu/mL had significantly lower I/M ratio than groups treated with PBS (P =.004) and Ad.LacZ (P =.002). Similarly, Ad.UG group at 0.68 × 1011 pfu/mL had significantly lower I/M ratio than PBS (P =.006) and Ad.LacZ (P =.003) controls. The two Ad.UG groups were not statistically different, nor were PBS and Ad.LacZ groups. Results shown as mean ± SEM and are significant at P <.008. I/M, Intima-media; PBS, phosphate-buffered saline. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and The American Association for Vascular Surgery, a Chapter of the International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 Representative carotid artery histology. Hematoxylin and eosin–stained cross sections of carotid arterial walls harvested 2 weeks after injury and treatment with PBS (A), Ad.LacZ (B), and Ad.UG at 1.35 × 1011 pfu/mL (C). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2000 Society for Vascular Surgery and The American Association for Vascular Surgery, a Chapter of the International Society for Cardiovascular Surgery Terms and Conditions

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