1. Histology of lung tissue from preterm lambs ventilated for 3 days with invasive intermittent mandatory ventilation (IMV) (A and C) or noninvasively with nasal high-frequency ventilation (HFV) (B and D).
Histology of lung tissue from preterm lambs ventilated for 3 days with invasive intermittent mandatory ventilation (IMV) (A and C) or noninvasively with nasal high-frequency ventilation (HFV) (B and D). Each row of panels has the same magnification (see scale bars). The gestation control fetal lambs were (1) delivered at the gestation age that the preterm lambs were delivered (FA132) or (2) delivered at the gestation age when the preterm lamb studies were completed (FA136). The terminal respiratory unit (TRUs) in the preterm lambs that received nasal HFV (B and D) have smaller and more uniform distal air spaces (DASs), more and thinner alveolar secondary septa (arrowhead in A and B), and thinner distal air-space walls (arrow in C and D) than the TRUs in the preterm lambs that received IMV (A and C). The TRUs in the preterm lambs that received nasal HFV are structurally similar to the TRUs in the FA136 gestation control lambs (F and H). On the other hand, the TRUs in the preterm lambs that received IMV (A and C) are structurally similar to the TRUs in the FA132 gestation control lambs (E and G). (From Reference 79, with permission.)‏
Robert M DiBlasi Respir Care 2011;56:
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