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Reduced-Intensity Conditioning Stem Cell Transplantation: Comparison of Double Umbilical Cord Blood and Unrelated Donor Grafts  Yi-Bin Chen, Julie Aldridge,

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Presentation on theme: "Reduced-Intensity Conditioning Stem Cell Transplantation: Comparison of Double Umbilical Cord Blood and Unrelated Donor Grafts  Yi-Bin Chen, Julie Aldridge,"— Presentation transcript:

1 Reduced-Intensity Conditioning Stem Cell Transplantation: Comparison of Double Umbilical Cord Blood and Unrelated Donor Grafts  Yi-Bin Chen, Julie Aldridge, Haesook T. Kim, Karen K. Ballen, Corey Cutler, Grace Kao, Deborah Liney, Greg Bourdeau, Edwin P. Alyea, Philippe Armand, John Koreth, Jerome Ritz, Thomas R. Spitzer, Robert J. Soiffer, Joseph H. Antin, Vincent T. Ho  Biology of Blood and Marrow Transplantation  Volume 18, Issue 5, Pages (May 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Cumulative incidence of grade II-IV acute GVHD. Cumulative incidence at 200 days was 14.1% in dUCB and 20.3% in URD groups (P = .32). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of chronic GVHD. The 2-year cumulative incidence of chronic GVHD was 21.9% in dUCB and 53.9% in URD groups (P > .0001). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 NRM and relapse. The 2-year cumulative incidence of NRM was 25.1% in dUCB versus 7.3% in URD groups (P = .0009). The 2-year cumulative incidence of relapse was 39.3% in dUCB versus 48.5% in URD groups (P = .09). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Causes of NRM after dUCBT (n = 16). “Donor onc” refers to donor cell-derived malignancy. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 PFS for patients undergoing dUCBT and URD RIC HSCT.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

7 Figure 6 OS (PFS) for patients undergoing dUCBT and URD RIC HSCT.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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