1. Outcomes
Number
of events†
Total
person-years†
aHR‡ (95%CI)
Forest plot
Primary Outcomes MI
Primary analysis
1,046
1,070,551.6
1.48( )
Sensitivity 1
324
263,844.5
1.70( )
Sensitivity 2
5,527
106,7051.0
1.31( )
Sensitivity 3
1,388
934,918.4
1.57( )
Sensitivity 4
1,209
891,076.7
1.43( )
Sensitivity 5
1,711
1,175,766.7
1.51( )
Sensitivity 6
1,765
1,218,212.2
1.47( )
Sensitivity 7
3,281
2,021,315.8
1.13( )
Sensitivity 8
1,576
1,069,940.4
Sensitivity 9
1,059
1,076,847.7
1.42( ) HF
5,499
1,127,507.4
1.46( )
952
263,527.1
1.69( )
48,658
1,029,917.0
1.23( )
4,890
933,125.9
1.47( )
2,707
890,407.3
1.45( )
6,051
1,173,212.9
1.43( )
6,274
1,215,480.2
1.41( )
12,189
2,009,616.2
1.21( )
1,067,789.9
5,859
1,074,159.9
1.65( )
Stroke
116
1,130,832.0
0.99( ) 20
264,025.3
1.20( )
32,505
1,043,023.8
1.08( )
105
935,707.7
1.08( ) 70
891,819.4
1.00( )
129
1,176,881.6
1.03( )
132
1,219,406.1
1.01( )
266
2,025,517.3
0.99( )
1,070,868.2
122
1,077,385.9
1.15( )
0.5
1.0
1.5
2.0
2.5
3.0
aHR
0.5
1.0
1.5
2.0
2.5
3.0
aHR
0.5
1.0
1.5
2.0
2.5
3.0
aHR
Figure S3. Hazard ratio for MI, HF and stroke in primary analysis and sensitivity analysis 1-9 (DPP-4Is vs BGs)