1. Structure of cefiderocol (hybrid 10), previously known as S , derived by linking ceftazidime to the siderophore catechol 2-chloro-3,4-dihydroxybenzoic acid.
Structure of cefiderocol (hybrid 10), previously known as S , derived by linking ceftazidime to the siderophore catechol 2-chloro-3,4-dihydroxybenzoic acid. This β-lactam–siderophore hybrid possesses potent antibacterial activity against metallo-β-lactamase-producing Gram-negative bacilli.
Ronald Domalaon et al. Clin. Microbiol. Rev. 2018; doi: /CMR