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Fig. 3 The rs55958994 risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs55958994 risk enhancer is a hub for intrachromosomal.

Published byAnnegret Koenig Modified over 5 years ago

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Presentation on theme: "Fig. 3 The rs55958994 risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs55958994 risk enhancer is a hub for intrachromosomal."— Presentation transcript:

1 Fig. 3 The rs55958994 risk enhancer is a hub for intrachromosomal and interchromosomal interactions.
The rs risk enhancer is a hub for intrachromosomal and interchromosomal interactions. (A) Circos plot showing genome-wide interactions indicated by curves extending from the bait locus; intrachromosomal and interchromosomal interactions are in red and blue, respectively. Interactions reproducible in at least two biological replicates are shown. (B) A comparison of gene expression fold changes based on RNA-seq and the corresponding Capture-C signal counts are shown. A total of 2936 genomic loci with differential expression (adjusted P < 0.1) are shown on the plot. Among them, 219 loci with both reproducible interaction (Capture-C support > 1) and significant expression change between KO and WT (adjusted P < 0.1 and log 2 fold change > 1 or <−1) are shown in blue. (C) qRT-PCR analysis of mRNA (independent mRNA library) levels of potential target genes of the risk enhancer based on analysis in enhancer-deleted (KO) cells. Data represent means ± SEM of three independent experiments. ***P < 0.001, **P < 0.01 compared with corresponding KO cells. Yuyang Qian et al. Sci Adv 2019;5:eaaw6710 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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