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KLF4 is a key determinant in the development and progression of cerebral cavernous malformations qRT–PCR analysis of Klf4 during disease progression at.

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Presentation on theme: "KLF4 is a key determinant in the development and progression of cerebral cavernous malformations qRT–PCR analysis of Klf4 during disease progression at."— Presentation transcript:

1 KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
qRT–PCR analysis of Klf4 during disease progression at different times (P3, P5, and P9) after tamoxifen‐induced Ccm1 recombination (P1) in freshly isolated brain ECs derived from WT and iCCM1 mice. Data are mean ± SD (n = 3 in each group). Fold changes are relative to WT animals. A two‐tailed unpaired t‐test was performed. *P = 0.0143, **P = 0.002, ##P =  Representative immunostaining of KLF4 (red) in combination with PECAM1 (green, to identify ECs) in brain sections from iCCM2, iCCM3 mice, and their relative WT controls (one out of three performed). Cell nuclei are visualized with DAPI; dotted area highlights lesion area. Scale bars: 50 μm. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO Mol Med, Volume: 8, Issue: 1, Pages: 6-24, First published: 26 November 2015, DOI: ( /emmm )


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