1. Medroxyprogesterone acetate does not antagonize estrogen-induced increases in endothelium-dependent vasodilation: potential clinical implications 
Hillary Dinh, B.S., Lauren Nathan, M.D. 
Fertility and Sterility 
Volume 78, Issue 1, Pages (July 2002)
DOI: /S (02)

2. FIGURE 1
Effects of E2 and MPA on endothelium-dependent vasodilation produced by ACh. Mean ± SEM percentage relaxation of endothelium-intact aortic rings from ovariectomized (OVX) female rats in response to different concentrations of ACh. Aortic rings were submaximally contracted (70%–80% of that produced by 122 mM KCl) with phenylephrine before obtaining cumulative responses to ACh. Relaxation was significantly enhanced in aortic rings from E2 (■)-treated or E2 plus MPA (▴)-treated OVX rats as compared with the placebo-treated group (•). ∗P<.001 compared with placebo group. The concentration response curves from E2-treated or E2 plus MPA-treated rats overlapped and showed no statistically significant difference between the two groups (P>.05).
Dinh. Medroxyprogesterone acetate and vasomotion. Fertil Steril 2002.
Fertility and Sterility  , DOI: ( /S (02) )

3. FIGURE 2
Effects of E2 and MPA on the tone-dependent release of NO. Mean ± SEM percentage contraction of endothelium-intact aortic rings from ovariectomized (OVX) female rats in response to different concentrations of NG-nitro-l-arginine methyl ester (l-NAME). The aortic rings were moderately contracted (30%–50% of that produced by 122 mM KCl) by phenylephrine before cumulative responses were obtained to l-NAME. The magnitude of contraction was significantly greater in aortic rings from E2) (■)-treated or E2 plus MPA (▴)-treated OVX rats. ∗P<.001 compared with placebo group (•). There was no significant difference between E2 or E2 plus MPA-treated rats (P>.05).
Dinh. Medroxyprogesterone acetate and vasomotion. Fertil Steril 2002.
Fertility and Sterility  , DOI: ( /S (02) )

4. FIGURE 3
Effect of E2 and MPA on endothelium-independent vasodilation induced by GTN: mean ± SEM percentage relaxation of endothelium-denuded aortic rings from ovariectomized (OVX) female rats in response to different concentrations of GTN. Aortic rings were submaximally contracted (70%–80% of contraction produced by 122 mM KCl) with phenylephrine before cumulative responses to GTN were obtained; responses were similar in all three groups (P>.05). •, placebo; ■, E2; ▴, E2 plus MPA.
Dinh. Medroxyprogesterone acetate and vasomotion. Fertil Steril 2002.
Fertility and Sterility  , DOI: ( /S (02) )

5. FIGURE 4
Effect of E2 and MPA on uterine weight. Mean ± SEM uterine weight. Uterine horns from individual rats in each group were collected and weighed. Uterine weight was significantly higher from E2-treated rats when compared with placebo-treated or E2 plus MPA-treated rats. ∗P<.001 compared with placebo group. †P<.001 compared with E2-treated rats.
Dinh. Medroxyprogesterone acetate and vasomotion. Fertil Steril 2002.
Fertility and Sterility  , DOI: ( /S (02) )