1. The Cell Theory, Cell Cycle & Mitosis

2. Outline Animal of the day! Cell cycle, mitosis, cancer
Warning: not for the faint of heart
Cell cycle, mitosis, cancer

3. Animal of the day! Cymothoa exigua (tongue-eating louse)
a parasitic crustacean
The parasite enters through gills
Attach to the tongue
Eats away the tongue
Become the new tongue

5. The Cell Theory
1. All living things are composed of cells. 2. Cells are the basic units of living organisms. 3. All cells come from pre-existing cells.

6. Why are Cells so Tiny? Your body contains 100 trillion cells.
Cells take in nutrients and dispose of waste through the cell membrane.

7. Why are Cells so Tiny?
As cells grow larger, the volume grows faster than the membranes’ surface area.
When the cell becomes too large to absorb enough nutrients it must divide.

8. Why do Cells Divide? Growth: Repair: Reproduction:
To increase the number of cells in the body.
Repair:
To replace dead, damaged or old cells.
Reproduction:
Can make exact copies (clones).

9. The Cell Cycle
Every hour, about 1 billion of your cells die and another 1 billion are made.
Body cells go through several stages in their lifetime called the Cell Cycle.

10. The Cell Cycle The Cell Cycle has 2 parts: 1. Interphase:
Cell repairs any damages, re-energizes, grows and prepares for division.
2. Mitosis & Cytokinesis:
Division of the cell into 2 identical “daughter” cells.

11. Interphase
Longest stage of the cell cycle. About 90% of the time spent here.
Divided into three phases.

12. Interphase First Gap Phase (G1):
Cells grow in size. New proteins and organelles are made.
Synthesis Phase (S):
DNA is replicated (known as chromatin).
Second Gap Phase (G2):
Cells prepare for division.

13. Cell Division Mitosis (division of the nucleus)
Prophase
Metaphase
Anaphase
Telophase
Cytokinesis (division of the cytoplasm)

14. The Nucleus

15. Chromosomes Hereditary information. Contained within the nucleus.
Human cells contain 23 pairs of chromosomes.
When a cell divides, each daughter cell gets the same pairs of chromosomes.

16. Diploid and Haploid Diploid – two pairs of chromosomes
E.g. humans have 23 pairs of chromosomes in somatic (body) cells
Haploid – 1 of each chromosome
E.g. in human sex cells, sperm and egg (just 23 chromosomes)

17. Chromosomes Composed of DNA and proteins.
A gene is a segment of DNA that codes for a particular trait.

18. Prophase Nuclear membrane breaks down
Chromatin condenses to form paired chromosomes (sister chromatids).
Centrioles move to each pole.
Nucleolus disappears.

19. Metaphase Spindle fibers attach to centromere.
Chromosomes line up at metaphase plate.

20. Anaphase Spindle fibers shorten.
Sister chromatids separate and move to opposite poles.

21. Telophase & Cytokinesis
Cell membrane pinches inwards.
Cytoplasm splits in half.
Cells return to interphase.

22. Plant vs. Animal Cell

23. Visualizing the Cell Cycle
The stages of the cell cycle are used to understand the process.
In reality it is a continuous process.
These animations and video depict this:

24. Go Phase Cells can enter a resting phase called Go.
E.g., nerve cells in the brain stop dividing when the brain is developed and cannot reenter the cell cycle.

25. Cell Death Necrosis: Apoptosis: Cells may die due to external factors.
E.g., Toxins, infections, trauma.
Apoptosis:
The controlled death of old cells.
E.g., White blood cells divide to fight viral infections. When they are no longer required, they undergo apoptosis.

26. Cancer
Genetic mutations can cause cells to undergo abnormal cell division.
Instead of apoptosis, these cells divide uncontrollably.

27. Cancer

28. Cancer
Cell division occurs so fast that cells pile up on top of one another, forming a tumor.
Reduces the effectiveness of the surrounding tissue.

29. Cancer Changes to these abnormal cells in the tumor can create cancer.
May invade and destroy neighbouring cells.
May stimulate other cells to start replicating uncontrollably, thus spreading cancer and causing different types of cancer.