1. Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion 
Teruki Yanagi, MD, Masashi Akiyama, MD, PhD, Satoru Aoyagi, MD, Akihiko Shibaki, MD, PhD, Akihiro Homma, MD, Hiroshi Shimizu, MD, PhD 
Journal of the American Academy of Dermatology 
Volume 54, Issue 2, Pages (February 2006)
DOI: /j.jaad
Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

2. Fig 1
Cisplatin infusion chemotherapy induced cutaneous pigmentation restricted to the right cheek. A, Skin around the tumor before intra-arterial chemotherapy. B, Cutaneous pigmentation 10 days after the chemotherapy. Marked, dark-brown pigmentation was seen in the right cheek and the lips (arrowheads).
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

3. Fig 2
Skin biopsy specimen from the pigmented area on the right cheek. A, An increased number of melanocytes in the basal layer and basal melanosis were observed. B, Melanin staining clearly demonstrated the basal melanosis. C, Transmission electron microscopy demonstrated showed that melanocytes in the basal cell layer were producing a large number of melanosomes. Inset, Mature melanosomes were abundant in the cytoplasmic processes of a melanocyte. (A, Hematoxylin-eosin stain; B, Fontana-Masson stain; original magnifications: A, ×100; B, ×100; C, ×7000; inset, ×15,000.)
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad )
Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions