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Examples of tobramycin-efflux pump hybrids: tobramycin linked to 1-(1-naphthylmethyl)-piperazine (NMP) (hybrid 14), tobramycin linked to paroxetine (hybrid 15), and tobramycin linked to the dibasic peptide (DBP) analog d-Ala–d-hPhe–aminoquinoline (MC-04,124) (hybrid 16). Examples of tobramycin-efflux pump hybrids: tobramycin linked to 1-(1-naphthylmethyl)-piperazine (NMP) (hybrid 14), tobramycin linked to paroxetine (hybrid 15), and tobramycin linked to the dibasic peptide (DBP) analog d-Ala–d-hPhe–aminoquinoline (MC-04,124) (hybrid 16). All three tobramycin-based hybrids contain a 12-carbon-long aliphatic (C12) hydrocarbon linker. Ronald Domalaon et al. Clin. Microbiol. Rev. 2018; doi: /CMR
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