1. Drugs will be different in:
PHARMACOLOGY
Science dealing with interactions between living systems and molecules, especially chemicals from outside the body.
Drugs will be different in:
Size--most small
Shape--to fit receptor
Chemical nature--acid/base

2. Drug-body interaction
Pharmacodynamic:
What drug does to you
a) mimic or inhibit normal physiological/biochemical processes or inhibit pathological processes in animals or
(b) inhibit vital processes of endo- or ectoparasites and microbial organisms.
Pharmacokinetic:
What you do to drug(absorb, distribute, metabolize,eliminate)

3. Distribution: Depends on Blood Flow and Blood Brain Barrier

4. Excludes ionized
substances;
Active transport
mechanisms;
Not uniform – leaky
(circumventricular areas)

5. Get the drug in: Oral Inhale Topical Transdermal Subcutaneous
Intramuscular
Buccal
Sublingual
Rectal
Parenteral---must skip the GI tract to avoid stomach acid(some penicllins and insulin)

6. DRUG GROUPS Antibiotics Antifungals Antivirals Antiretrovirals
Affective disorders
Insomnia
CNS disorders
Respiratory agents
Gastrointestinal agents
Urinary system
Cardiovascular
Anticoagulant
Hyperlipidemia
Narcotic and opoid analgesics
Non-narcotic analgesics
Thyroid

7. DRUG GROUPS CONT Hormone replacement Bone disease Corticosteroids
Hypoglycemic
Topical
chemotherapy

8. first order kinetics first order kinetics-----’halflife is 2 hrs’
6 units in blood level at start. 3 units at 2hrs, 1.5 units at 4 hours, .75 units at 6 hours,ect
zero order kinetics---starts at first order kinetics until a threshold is hit then eliminates at a constant rate