1. Bio-Rad Overview and Statement of Interests

2. Bio-Rad Overview
Leading global provider of sophisticated products for life science research & clinical diagnostics markets
Founded in 1952
Develop, manufacture and market products to enable discovery
Diversified and complimentary mix of products & technologies
Sales exceeded $2 billion in 2015
Nearly 65 years of strong performance
Offices and facilities around the world
More than 8,000 employees worldwide
Listed on the NYSE (BIO)

3. Business Segments Life Science & Clinical Diagnostics
Manufacture and distribute 10,000+ products
>80% of sales from products in which Bio-Rad has a leading market position
Develop strong, long-lasting relationships with our customers
Products help people live longer, healthier lives
Cont…

4. Life Science Group
Products used in genomics, proteomics, cell biology, life science education and food safety
Separation, purification and analysis of biological materials
More than 5,000 products
Strong relationships with the research community
Natural linkage to clinical diagnostics

5. Circle of Discovery Genotyping & Gene Expression
(PCR & qPCR)
Gene Transfer & Modulation
Protein Expression
(multi-analyte detection)
Protein Quantification
(western blotting)
Food Safety
(food pathogen testing)
Biological research can be categorized into 3 fundamental areas: Cell Biology, Genomics, Proteomics.
While Bio-Rad products are integral to all of these areas of research, we have focused primarily on the study of genes and proteins.
There is an increasing interest, on the part of our customers, to study cells and we have now turned some of our attention to the growing area of cell analysis and recently introduced new products in this area.
Customers include universities and medical schools, industrial research organizations, government agencies, pharmaceutical manufacturers, biotechnology researchers, food producers and food testing laboratories.
Protein Purification
(chromatography)
Digital Biology
(Droplet Digital PCR)
Cellular Imaging
Cell Sorting & Analysis 9

6. Revolutionizing Science
Bio-Rad is a leader in digital genomics
Innovative technologies provide digital answers to complex biological questions
100s of peer-reviewed publications
Applications in life science research & diagnostics
Our core droplet partitioning technology is enabling breakthroughs in
Our Digital Biology Group, with centers is Pleasanton, California and Cambridge, Massachusetts are seeing applications of this technology center around cancer-rare mutation detection-and residual disease monitoring.
Sensitivity and precision of ddPCR is proving to be an enabling support technology
This new technology continues to grow in popularity as evidenced not only by placements of our QX 200 instrument but also publications about the use of this technology (100s of peer-reviewed publications so far)…
Liquid biopsy
Cancer genotyping
Biomarker detection
Environmental monitoring
Prenatal testing
Pathogen detection
Single-cell sequencing 6

7. Focus Areas – Life Science Research
Products and technologies that complement our core leadership in Life Sciences and digital biology
Single cell biology (genomics and proteomics)
Protein characterization
Digital genomics and translational research
New generation sequencing technology

8. Needs – Life Science Research
Core benefit: Targeting new technologies / technical approaches that provide complete solutions to our customers in Life Science Research
Core value: Product / application should provide well defined benefits for researchers over existing products - with simplified workflows and ease of use
Target population: Academic researchers, biotechnology and pharmaceutical researchers, food safety and science educators
Target market: Large and growing and falling into a focus area
Technical considerations:
Instrument target costs
Consumable target costs
Technology should be scalable for manufacturing
Maximal IP protection for the individual technology / application
Regulatory requirements should be met globally
Safety profile of technology compatible with product use

9. Clinical Diagnostics Group
Products for medical screening and diagnostics
More than 3,000 products
“Gold Standard” products
Leadership positions
Quality Control Systems
Immunohematology
Diabetes Monitoring
HIV/Hepatitis
Autoimmune Testing
Products for laboratory diagnostics to diagnose a variety of human disorders.
Bio-Rad is a leading specialty diagnostics company.
Products incorporate a broad range of technologies used to detect, identify, and quantify substances in bodily fluids and tissues. Results are used as aids to support medical diagnosis, detection, evaluation and the monitoring and treatment of diseases and other medical conditions.

10. An Integrated Systems Approach
Quality controls
Infectious disease
AIDS/HIV
Blood Virus detection
Bacteriology
Diabetes monitoring
Genetic disease screening
Autoimmune testing
Blood typing
Specialized Testing
Instruments
Products consist of instruments and reagents typically provided to the customer as integrated package to allow a lab to generate reproducible test results.
In the center area are the primary markets we target; we have leading market positions in several areas:
Leader in A1C testing (considered the gold standard)
Leader in autoimmune testing (the BioPlex 2200 instrument)
Leader in quality controls (considered the gold standard) important to the lab, work on all instruments
Blood typing – able to serve small and large labs
Customers are primarily hospital labs, reference, labs, transfusion labs, and physician office labs worldwide.
Diagnostic Tests
Quality Controls 7

11. Focus Areas – Clinical Diagnostics
Products and technologies that will have strong growth potential in the future of health care
Microbiome
Point of care technologies
Microbiology, including antibiotic susceptibility
New biomarkers
Food safety
Wearables, mHealth

12. Needs – Clinical Diagnostics
Core benefit: Targeting new diagnostic tests that provide clinicians and health care providers a complete solutions (assay + instrument)
Core value: Product / application should provide benefits for clinical labs over existing products - with simplified workflows and ease of use
Target population: Commercial diagnostic labs, blood banks, hospitals, and emerging testing labs
Target market: Large and growing and falling into a focus area
Technical considerations:
Instrument and consumable target costs
Assay complexity, precision and sensitivity
Technology should be scalable for manufacturing
Reimbursement plan needs to be defined
Maximal IP protection
Regulatory requirements should be met globally
Safety profile of technology compatible with product use