1. Impact of CMV congenital infection on olfactory discrimination in adult male mice.
Impact of CMV congenital infection on olfactory discrimination in adult male mice. A, B, Graph depicting the percentage of correct responses in each block of the easy (A) discrimination task between isoamylacetate (S+) and anethol (S−) or the difficult (B) discrimination tasks between their binary mixtures. The mixture ratio of isoamylacetate and anethol is indicated on the graph. C–E, Percentage of mice that did not reach the performance criterion for the discrimination task between isoamylacetate and anethol (C), d-limonene and citronellal (D), and d-limonene and anethol (E). F, Long-term memory test. To assess olfactory memory, mice were trained during 5 consecutive days to recall distinguishing d-limonene and anethol. Mice were then retested at W16 following the end of the training session (W12). In A, B, and F, a score of 50% corresponds to the success rate expected on the basis of chance alone (dashed line). Results in A, B, and F are expressed as the mean ± SEM of correct response. n = 8 CMV, n = 11 CTL. p-values were calculated by ANOVA with repeated-measures (A, B), Gehan–Breslow–Wilcoxon test (C–E), or Mann–Whitney test (F). *p < 0.05, **p < 0.01.
Françoise Lazarini et al. J. Neurosci. 2018;38:
©2018 by Society for Neuroscience