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Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy Helena J. Teede, Ph.D., Caroline Meyer, Ph.D., Samantha K. Hutchison, M.B., B.S., Sophia Zoungas, Ph.D., Barry P. McGrath, M.D., Lisa J. Moran, Ph.D. Fertility and Sterility Volume 93, Issue 1, Pages (January 2010) DOI: /j.fertnstert Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 Changes in AUC OGTT insulin (A) and AUC OGTT glucose (B) after metformin or OCP treatment for 6 months. Data are presented as mean ± SEM. Data were assessed with use of repeated-measures ANOVA with time as the within-subject factor and intervention as the between-subject factor. ∗Significant differential effect of treatment (P<.001) with decrease in AUC insulin for metformin (P=.003) and increase for OCP (P<.001). ∗∗Significant differential effect of treatment (P=.011) with increase in AUC glucose for OCP (P<.001). Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Changes in endothelial function: flow-mediated dilation (FMD) (A), vWF (B), PAI-1 (C), and ADMA (D) after metformin or OCP treatment for 6 months. Data are presented as mean ± SEM. Data were assessed with use of repeated-measures ANOVA with time as the within-subject factor and intervention as the between-subject factor. ∗Significant differential effect of treatment (P=.037) with increase in flow-mediated dilation for metformin (P=.017). ∗∗Significant differential effect of treatment (P=.038) for vWF with significantly higher vWF levels for the OCP group after treatment (P=.012). †Significant differential effect of treatment (P=.017) with greater decrease in PAI-1 for OCP (P<.001) and decrease in PAI-1 for metformin (P=.044). ††Significant differential effect of metformin or OCP treatment (P<.001) for ADMA for all subjects. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions
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