1. Botanical Support for Allergies
Practitioner Call
April 13th 9:00 am
Glen Nagel, ND
Sponsored by Wise Woman Herbals

2. Disclaimer
Today’s call is presented by Dr. Glen Nagel and sponsored by Wise Woman Herbals. All verbal and written information provided on today’s practitioner call is solely on behalf of the presenter.
THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD & DRUG ADMINISTRATION. IT IS NOT INTENDED TO TREAT, DIAGNOSE, PREVENT OR CURE ANY DISEASE AND SHOULD NOT REPLACE MEDICAL CARE.

3. Therapeutic Triangle A Balanced Approach
Traditional Use/ Ethnobotanical
Personal/ Doctor Experience
Scientific Research Studies
Herb
Discuss the overview of the therapeutic triangle, the goal of this slide to show that besides research there are other ways to measure a herbs effectiveness.
A Balanced Approach

4. Herbal Synergy: How Do Herbs Work?
Essence
Placebo
Organoleptics
Dosing
Therapeutic Outcome
Concentration and Extractions methods
Herbal Chemistry
Signatures
The goal of this slide is that therapeutic outcome is based on many holistic aspects not just constituents and dosing.

5. Unchecked global warming will worsen respiratory allergies
Findings:
Unchecked global warming will worsen respiratory allergies
More airborne allergens could mean more asthma attacks

7. Three main factors related to climate change fuel increases in allergens. 
Carbon dioxide, the heat-trapping gas that is the primary cause of our warming planet, increases the growth rate of many plants and increases the amount and potency of pollen. 
Rising temperatures extend the growing season and the duration of allergy season.
And an extended spring season alters the amounts of blooms and fungal spores that are known to exacerbate allergy symptoms.

8. Seasonal Allergies…a Primer
Allergic reactions are sensitivities to substances, called allergens, that come into contact with the skin, nose, eyes, respiratory tract and gastrointestinal tract. They can be inhaled into the nose and lungs, swallowed or injected.
An estimated 50 million Americans (1 in 5) suffer from all types of allergies including indoor/outdoor, food & drug, latex, insect, skin and eye.
Allergy prevalence overall has been increasing since the early
1980s across all age, sex and racial groups.

9. Seasonal Allergies…a Primer
Allergy is the fifth leading chronic ailment in the U.S. among all ages, and the 3rd most common chronic disease among children under 18 years old.
Indoor/outdoor allergies are also known as allergic rhinitis, seasonal/perennial allergies, hay fever, and nasal allergies.
Approximately 40 million Americans have indoor/outdoor allergies as their primary allergy. Many people with allergies usually have more than one type.
Approximately 10 million Americans are allergic to cat dander, the most common pet allergy.
The most common indoor/outdoor allergy triggers are: tree, grass & weed pollen; mold spores; dust mite & cockroach allergen; and cat, dog & rodent dander.

10. Total Allergenic Load Concept
All allergies add up to create a total load, the more allergies the higher the load
The water can represent the allergies
The glass can represent the immune system
As long as you have room in your cup, your symptoms will be light
Once the water overflows the cup, many symptoms
Goal: Keep the glass half empty or more!
Half Empty: Good
Overload: Bad

11. Common Allergy Triggers
Allergies can be triggered by a variety of substances, known as allergens. These allergens are more often than not, proteins.
Potentially-allergenic proteins are all around us in the form of pollens, molds, dust mite feces, cat saliva (on their dander), food, etc. 

12. Common Allergy Triggers
Respiratory allergies are often triggered by inhaled substances. As such, many respiratory allergens are the most difficult to avoid, since moving to a different bio- region, where your plant allergen can be avoided, is not always possible.
Even then, you may simply find yourself responding to a new airborne allergen after a period of time. Likewise, many people faced with the option of getting rid of their allergenic feline friends, choose not to and continue to suffer with their allergy symptoms.
Avoidance is not always possible, for a myriad of reasons.

13. Seasonal Allergies…a Primer
Most allergies result from a combination of inheritance (genes) and environmental exposures (pollens, animal danders, etc.).
Being exposed to allergens at certain times when the body’s defenses are low or weak, such as after a viral infection or during pregnancy, also may contribute to the development of allergies. .

14. Allergic Response
Following the body's first exposure to the allergen, white blood cells produce antibodies to prepare the immune system for the next encounter with that same allergen.
This first exposure to pollen will not produce any outward allergic symptoms, but inside the IgE antibodies attach themselves to mast cells. Mast cells are cells that can be found in the respiratory system, gastrointestinal tract, and skin.
During the second and subsequent exposures to pollen, this allergen will combine with the IgE antibody and release chemicals, such as histamine, in the mast cells, thus producing the allergy symptoms of a runny nose, watery and/or itchy eyes, scratchy throat, swelling in the ears & sinuses and sneezing.

15. Herbal Actions to support Allergies
A number of pharmaceutical drugs attempt to either inhibit the formation of these compounds (e.g. COX-1 and COX-2 inhibitors) or prevent them from binding to their target receptors once they're formed (e.g. antihistamines).
Herbal anti-inflammatories are often able to provide an effective anti-inflammatory effect without the negative side- effects associated with the pharmaceutical steroidal and non-steroidal anti-inflammatory drugs (NSAIDs).
Herbs like Turmeric, Ginger, & Feverfew can help stabilize the mast cell response and prevent degranulation, before it occurs. This is a much better approach than trying to inhibit the enzymes after the arachidonic acid has been released.

16. Symptomatic Treatment: Limitations
Orthodox medical treatment of allergies usually involves a combination of allergen avoidance and symptom suppression. Of course, complete avoidance of an allergen is often difficult to impossible. With food allergies this goal might be readily attainable. With respiratory allergies, however, this is more often than not an infeasible approach.
On the other hand, you'll get little argument from most people that symptom suppression or management is a logical and necessary short-term goal. Even the so-called 'non-serious' symptoms of allergic rhinitis can be disabling and living day-after-day with these symptoms can become unbearable.
Symptom management is important. However, if there is no long-term strategy to correct the underlying mast cell instability, symptom suppression alone amounts to little more than a band-aid

17. 3 Keys to Helping Seasonal Allergies
Supportive Symptom management, using appropriate herbal medicines
Decongestants, tissue restoratives, mucolytics
Mast cell stabilization, using anti-inflammatories
Anti-inflammatories
Adrenal support
Modification of the underlying contributing factors
Avoidance of foods, pollens or animal dander
Immune support
Stress management
Cleansing & detoxification

18. Eyebright: Euphrasia off.

19. Eyebright: Euphrasia
Parts used: Aerial parts (dried), gather in late summer while in bloom
Constituents:
Iridoid glycosides (aucuboside, aucubin, are anti-inflammatory and antimicrobial)
Flavonoids (rutin, quercetin, apigenin glycosides)
Tannin (mild), acrid bitter principle, volatile oil, caffeic acid, ferulic acid, sterols, choline, fixed oils, fatty acids, vit. C, b- carotene, resin

20. Eyebright Actions: Uses:
Nourishing, toning & strengthening to mucus
membranes of the eyes, ears, nose, sinus, throat & bronchi
Antihistamine
Anti-inflammatory
Astringent
Uses:
Seasonal allergies, hay fever, allergic rhinitis
Hypersensitivity to airborne irritants
Sinusitis
Allergy symptoms affecting the eyes and ears
Conjunctivitis (take by mouth)
Dose: 1 full squeeze of the dropper bulb in 2 oz. of water, juice or tea, 2 to 5 times per day.
Flowering Eyebright
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

21. Urtica Leaf and Stem: Medicinal Use
Nutritional Alterative
Anti -Allergy
Diuretic
Anti-Arthritis
Sinus support
Liver support
Anti inflammatory
Mineral and protein source

22. Constituents of Urtica d.
Herb
Chlorogenic Acid
Caffeoylmalic Acid
Flavonoids
Essential Oil
Amino Acids
Minerals
Stinging Hairs
Acetylcholine
Histamine
Serotonin

23. Close up of stinging Trichomes from Uritca dioica

24. Nettles Indications
Tissue states: atrophy, stagnation, depression, toxicity
Indications: Low blood pressure, hair loss, mucus, diarrhea, swelling, edema.
Anemia of pregnancy, deficient lactation
Arthritis, gout, burns, hives
Atrophy or muscles or organs
Depletion, weakness
Allergies with protein sensitivities.
Pain, joint swelling and stiffness (Nettle sting)

25. Stinging Nettle Actions:
Nourishing tonic (loaded with vitamins, minerals & protein)
Alterative (detoxifying)
Antihistamine
Anti-inflammatory
Anti-rheumatic
Moderates allergic response
Hemostatic
Urinary tonic, mild diuretic
King of nutritional tonics!
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

26. Hydrastis canadensis: Goldenseal
Goldenseal and the common cold:
The antibiotic myth , mucus membrane tonic.
Never Used Historically for colds
No effect on viruses.

27. Goldenseal Hydrastis canadensis Native Appalachian Herb
Traditionally used to support
Sinus
Mucus membranes
Anti microbial
Excessive mucus production
Source of Berberine and Hydrastine
Golden colored roots, very bitter
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

28. Hydrastis canadensis: Goldenseal
Dosing:
Tincture 1to5, Take drops , TID
10% of a formula is often enough.
90% of Hydrastis is misused or incorrectly prescribed.

29. Thymus vulgaris: Garden Thyme
Family: Lamiaceae
Common name: Thymus 
Habitat: Thymus is wild and cultivated. It is native to the Mediterranean region and the mountains of Spain and Europe. Thymus is now cultivated throughout the world preferring sandy, dry soil.

30. Thymus vulgaris: Garden Thyme
Volatile oil ( %): inc. terpenes such as thymol (20- 55%), carvacrol (1-10%), borneol (up to 8%), cineol, p- cymene (14-45%), linalool (up to 8%)
Caffeic acid derivatives: rosmarinic acid
Flavonoids
Triterpenes: including, among others, ursolic acid (2%), oleanolic acid (0.6%)
Tannins, Bitters, Resin, Gums

31. Thymus Vulgaris
Medicinal Actions: Anti-septic, anti-helminthic, anti-viral, anti-bacterial, astringent, expectorant, secretolitic (decreases over-secretions), spasmolytic.
Always available at homes, make strong tea and gargle with Sage leaf.
Use for steam inhalations
Caution with Essential oil, strong!

32. Lobelia inflata Traditional Use: Part used: Constituents:
Use in folk medicine by Sammuel Thompson
Part used:
Aerial parts; collected at the end of flowering time. The seeds being twice the strength of the herb. Made with fresh leaf with seeds, acidified extract for better potency
Constituents:
Piperidine alkaloids ( %): chief alkaloids L-lobeline (alpha- lobeline); companion alkaloids including among others: Lobelanine, lobelanidine, norlobelanine, isolobinine
Pentacyclic triterpenes: beta amyrin
Other: chelidonic acid, carboxylic acid, resins, gums, fats
Flowering Lobelia inflata
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

33. Lobelia inflata Actions *
Lobelia is used primarily for its relaxant effects in the bronchioles. Its ability to relax the smooth muscle of the bronchioles make it an invaluable part of an acute or chronic asthma formula.
Systemically, Lobelia exerts powerful effects.
Lobelia reduces smooth muscle spasm and thus lowers arterial pressure and vascular tension.
Lobelia is anti spasmodic in muscular conditions
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

34. Lobelia inflata Too much or sensitive patient will cause vomiting
Stimulant and relaxant: dual nature
Small dose stimulant , large dose relaxing
Drop dosing best: drops up to 4 times per day
Cautions: Can cause Nausea and Vomiting if overdosed

35. Inula helenium Elecampane
Part used: Rhizome
Actions: Expectorant, anti-tussive, diaphoretic, stomachic, anti- bacterial
Specific indications: Irritating bronchial coughs , deep lung conditions.

36. Inula helenium Constituents:
Inulin, mucilage, triterpenes, bitter principle1
Antimicrobial eudesmanolides
Alantolactone, isoalantolactone, diplophyllin –sesquiterpene lactones3

37. Amoracia rusticana - Horseradish
Part used: fresh, raw, grated roots. Actions: decongestant, mucolytic, stimulant, diaphoretic, rubefacient, digestive stimulant Specific Indications: sinusitis, used topically for neuralgia and chilblains Constituents: sinigrin, a crystalline glucosinolate, which is decomposed in the presence of water by myrosin, an enzyme found also in the root, producing the volatile oil, allyl isothiocyanate, which is identical to that of Black Mustard seed.

38. Achillea millefolium (Yarrow)
Family: Asteraceae (Compositae)
Common name: Yarrow
Habitat: Introduced to North America from Europe.
Part used: Herb, Flowers, Root

39. Achillea millefolium: Yarrow
Thousand fold leaf
Aromatic sweet smell

40. Yarrow’s Actions Medical actions:
Tonic bitter (Cold), anti-inflammatory, carminative, spasmolytic, (volatile oil) diaphoretic (Warm),
Anti-hemorrhagic, Anti- inflammatory ,Anti allergenic
Antispasmodic, alterative, diuretic, astringent.

41. Upper Respiratory Support
Promotes normal healthy sinus passages and upper respiratory tract function Ingredients:
Achillea millefolium (yarrow)
Armoracia rusticana (horseradish)
Inula helenium (elecampane)
Mahonia spp. (Oregon grape)
Monarda fistulosa (wild bergamot beebalm)
Thymus vulgaris (thyme), Urtica dioica (nettles)

42. Happening Now!

43. Dr. Glen Nagel ND, RH (AHG)
Thank You!
Dr. Glen Nagel ND, RH (AHG)
(503)
Sponsored By:
Wise Woman Herbals
(541)