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Journal of Cystic Fibrosis

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1 Journal of Cystic Fibrosis
Measuring recovery in health-related quality of life during and after pulmonary exacerbations in patients with cystic fibrosis  Patrick A. Flume, Ellison D. Suthoff, Mark Kosinski, Gautham Marigowda, Alexandra L. Quittner  Journal of Cystic Fibrosis  DOI: /j.jcf Copyright © 2018 The Authors Terms and Conditions

2 Fig. 1 Analytic windows generated to assess CFQ-R domain scores and ppFEV1 measurements pre- and post-PEx from TRAFFIC/TRANSPORT trials. TRAFFIC/TRANSPORT study visits (examples: 2 patients, 1 with PEx occurring at week 14 and the other at week 5, given as the upper 2 bars) were arranged around PEx start dates, and PEx analytic windows were created on either side of the index date (lower bar). CFQ-R scores and ppFEV1 measurements occurring within each window were averaged. Journal of Cystic Fibrosis DOI: ( /j.jcf ) Copyright © 2018 The Authors Terms and Conditions

3 Fig. 2 Respiratory Symptoms and Physical Functioning CFQ-R scores. CFQ-R, Cystic Fibrosis Questionnaire–Revised; PEx, pulmonary exacerbation. *CFQ-R domain scores were significantly different compared with PExPre>8 (P < .05). †CFQ-R domain scores were significantly different compared with PEx1 (P < .05). Journal of Cystic Fibrosis DOI: ( /j.jcf ) Copyright © 2018 The Authors Terms and Conditions

4 Fig. 3 CFQ-R score pre- and post-PEx by PEx management for Physical Functioning. No statistical testing was performed between types of PEx management. CFQ-R, Cystic Fibrosis Questionnaire–Revised; IV, intravenous; PEx, pulmonary exacerbation. Journal of Cystic Fibrosis DOI: ( /j.jcf ) Copyright © 2018 The Authors Terms and Conditions

5 Fig. 4 CFQ-R scores with ppFEV1 pre- and post-PEx for Respiratory Symptoms and Physical Functioning. No statistical testing was performed. CFQ-R, Cystic Fibrosis Questionnaire–Revised; PEx, pulmonary exacerbation; ppFEV1, percent predicted forced expiratory volume in 1 s. Journal of Cystic Fibrosis DOI: ( /j.jcf ) Copyright © 2018 The Authors Terms and Conditions


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