1. For patients with type 2 diabetes and DN, follow-up time was divided into time spent in the following clinical states: DN, CVD, and ESRD in chronologic order as shown in this multistate model with age, diabetes duration, and DN duration as underlying time scales.
For patients with type 2 diabetes and DN, follow-up time was divided into time spent in the following clinical states: DN, CVD, and ESRD in chronologic order as shown in this multistate model with age, diabetes duration, and DN duration as underlying time scales. Numbers in boxes represent the sum of person-years in the state; numbers on the arrows are number of patients that change state with rates in % per year in the parentheses. Patients with CVD at baseline started in the CVD state (blue box); otherwise, all patients started in the DN state (green box). Green, DN only; blue, CVD; red, ESRD including doubling of p-creatinine; yellow, ESRD and CVD. Framed boxes with lighter colors represent those who died in the above-mentioned states.
Gudbjörg Andrésdóttir et al. Dia Care 2014;37:
©2014 by American Diabetes Association